Description

2,5-Dichloro-4-iodopyridine (CAS No. 796851-03-1) is a highly versatile halogenated pyridine derivative with the molecular formula C₅H₂Cl₂IN. This compound is an essential building block in pharmaceutical and agrochemical research, offering unique reactivity due to its electron-deficient pyridine core and strategically positioned halogen substituents. With a purity grade suitable for laboratory and industrial applications, it is supplied as a crystalline solid with excellent shelf stability under recommended storage conditions. Ideal for cross-coupling reactions, nucleophilic substitutions, and as a precursor in heterocyclic synthesis, this reagent is meticulously quality-controlled to ensure batch-to-batch consistency. Available in scalable quantities, it is packaged under inert conditions to maintain integrity.

Properties

• CAS Number: 796851-03-1
• Complexity: 101
• IUPAC Name: 2,5-dichloro-4-iodo-pyridine
• InChI: InChI=1S/C5H2Cl2IN/c6-3-2-9-5(7)1-4(3)8/h1-2H
• InChI Key: IWCZLVRNVBSAPH-UHFFFAOYSA-N
• Exact Mass: 272.86090
• Molecular Formula: C5H2Cl2IN
• Molecular Weight: 273.88
• SMILES: C1=C(C(=CN=C1Cl)Cl)I
• Topological: 12.9
• Monoisotopic Mass: 272.86090
• Synonyms: 2,5-DICHLORO-4-IODOPYRIDINE, 796851-03-1, DTXSID50694736, DTXCID50645485, 2,5-dichloro-4-iodo-Pyridine, MFCD13185538, PYRIDINE, 2,5-DICHLORO-4-IODO-, 4-Iodo-2,5-dichloropyridine, SCHEMBL689954, 2,5-dichloro-4-iodo pyridine, IWCZLVRNVBSAPH-UHFFFAOYSA-N, AKOS015851101, AB66762, CS-W021519, AC-33342, AS-19888, SY019689, DB-024251

2,5-Dichloro-4-iodopyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. Its reactive iodine and chlorine sites enable efficient Suzuki, Stille, and Negishi couplings for constructing complex molecular architectures. Researchers leverage this compound in drug discovery for modifying pyridine-based scaffolds to enhance bioactivity. It is also employed in material science for developing functionalized ligands and catalysts.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Skin Sens. 1 (100%)
• Eye Dam. 1 (100%)
• STOT SE 3 (100%)

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