Description

2,2-Difluoroethan-1-amine hydrochloride (CAS No. 79667-91-7) is a high-purity organic compound with the molecular formula C₂H₆ClF₂N. This hydrochloride salt of 2,2-difluoroethylamine is a versatile building block in pharmaceutical and agrochemical research, offering excellent reactivity for nucleophilic substitution and other synthetic transformations. Its crystalline solid form ensures easy handling and accurate dosing in laboratory settings. Ideal for medicinal chemistry, this compound is rigorously tested for purity and stability, making it a reliable choice for researchers developing novel fluorinated molecules. Store in a cool, dry place under inert conditions to maintain optimal quality.

Properties

• CAS Number: 79667-91-7
• Complexity: 21.6
• IUPAC Name: 2,2-difluoroethanamine;hydrochloride
• InChI: InChI=1S/C2H5F2N.ClH/c3-2(4)1-5;/h2H,1,5H2;1H
• InChI Key: YSVKPVHTHFECBE-UHFFFAOYSA-N
• Exact Mass: 117.0156832
• Molecular Formula: C2H6ClF2N
• Molecular Weight: 117.52
• SMILES: C(C(F)F)N.Cl
• Topological: 26
• Monoisotopic Mass: 117.0156832
• Synonyms: 2,2-difluoroethan-1-amine hydrochloride, 810-381-2, 79667-91-7, 2,2-Difluoroethylamine hydrochloride, 2,2-difluoroethanamine hydrochloride, C2H6ClF2N, 2,2-difluoroethanamine;hydrochloride, MFCD04038283, 2,2-Difluoroethanamine HCl, 2,2-Difluoroethanamine, HCl, Ethanamine, 2,2-difluoro-, hydrochloride, difluoroethylamine hydrochloride, SCHEMBL1031409, DTXSID10593019, 2,2-difluoroethanaminehydrochloride, BCP34612, 2,2-Difluoro-ethylamine hydrochloride, AKOS007930501, SB75561, 1-Amino-2,2-difluoroethane hydrochloride, BS-17593, SY029656, CS-0121259, EN300-96615, 2,2-Difluoroethan-1-amine–hydrogen chloride (1/1), Z1295543893

Application

2,2-Difluoroethan-1-amine hydrochloride is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals and bioactive compounds. Its difluoroethyl group enhances metabolic stability and lipophilicity in drug candidates, making it valuable for medicinal chemistry applications. Researchers also employ it in the development of agrochemicals and specialty materials requiring fluorine incorporation. The hydrochloride salt form improves solubility in polar solvents, facilitating reactions in aqueous or mixed-phase systems.

Safety and Hazards

GHS Hazard Statements

• H301 (95%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (95%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (95%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (95%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (95%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (95%)
• Skin Irrit. 2 (95%)
• Eye Dam. 1 (95%)
• STOT SE 3 (95%)
• Aquatic Chronic 3 (95%)

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