Description

1-(Piperidin-4-yl)-1H,2H,3H-imidazo[4,5-b]pyridin-2-one dihydrochloride (CAS No. 781649-84-1) is a high-purity organic compound with the molecular formula C₁₁H₁₆Cl₂N₄O. This dihydrochloride salt derivative features a piperidin-4-yl group attached to an imidazo[4,5-b]pyridin-2-one core, making it a valuable intermediate for pharmaceutical research and medicinal chemistry applications. The compound is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring consistency for experimental use. It is soluble in water and polar organic solvents, facilitating its use in various reaction conditions. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain stability. This product is ideal for researchers investigating kinase inhibitors, CNS-targeting drugs, or novel heterocyclic scaffolds.

Properties

• CAS Number: 781649-84-1
• Complexity: 277
• IUPAC Name: 1-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-2-one;dihydrochloride
• InChI: InChI=1S/C11H14N4O.2ClH/c16-11-14-10-9(2-1-5-13-10)15(11)8-3-6-12-7-4-8;;/h1-2,5,8,12H,3-4,6-7H2,(H,13,14,16);2*1H
• InChI Key: OHUCGNJZMRINKX-UHFFFAOYSA-N
• Exact Mass: 290.0701165
• Molecular Formula: C11H16Cl2N4O
• Molecular Weight: 291.17
• SMILES: C1CNCCC1N2C3=C(NC2=O)N=CC=C3.Cl.Cl
• Topological: 57.3
• Monoisotopic Mass: 290.0701165
• Synonyms: 1-(piperidin-4-yl)-1H,2H,3H-imidazo[4,5-b]pyridin-2-one dihydrochloride, 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one dihydrochloride, 1-(piperidin-4-yl)-1H,2H,3H-imidazo(4,5-b)pyridin-2-one dihydrochloride, 1-Piperidin-4-yl-1,3-dihydroimidazo(4,5-b)pyridin-2-one dihydrochloride, 937-843-7, 781649-84-1, 1-(Piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one dihydrochloride, 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one dihydrochloride, 2-Oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride, 1-piperidin-4-yl-3H-imidazo[4,5-b]pyridin-2-one;dihydrochloride, 1-(Piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one (Hydrochloride), OHUCGNJZMRINKX-UHFFFAOYSA-N, MFCD14705173, 1,3-Dihydro-1-(4-piperidinyl)-2H-imidazo[4,5-b]pyridin-2-one Dihydrochloride, SCHEMBL438908, CHEMBL3498426, DTXSID80624480, CS-B1304, AKOS015917815, BG-0075, SB43943, DB-354096, A1-02854, 1-(PIPERIDIN-4-YL)-1H,2H,3H-IMIDAZO-[4,5-B]PYRIDIN-2-ONE 2HCL, 1-(Piperidin-4-yl)-1H,2H,3H-imidazo-[4,5-b]pyridin-2-one dihydrochloride, 1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one bis HCl salt, 1-(Piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-onedihydrochloride, 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one-dihydrochloride, 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-on-dihydrochloride, 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one-dihydrochloride, 1-(Piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one–hydrogen chloride (1/2), 1-piperidin-4-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one dihydrochloride, 1-piperidin-4-yl-1,3-dihydro-2H-imidazolo[4,5-b]pyridin-2-one dihydrochloride, 2-oxo-1-piperidinium-4-yl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-4-ium dichloride

Application

This compound serves as a key building block in the synthesis of potential kinase inhibitors due to its imidazopyridine scaffold. Researchers utilize it in structure-activity relationship (SAR) studies targeting neurological disorders. The piperidine moiety enhances blood-brain barrier penetration, making it valuable for CNS drug discovery programs. It’s also employed in fragment-based drug design for oncology targets.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)

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