Description

5-Bromo-2-chloro-4-methylpyridine (CAS No. 778611-64-6) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₅BrClN. This heterocyclic compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring bromo and chloro substituents on a methylated pyridine ring, enables selective functionalization for the development of complex molecules. Available in >98% purity (HPLC), this product is rigorously tested for consistency, stability, and low trace metal content. Packaged under inert gas in amber glass vials to prevent degradation. Ideal for Suzuki couplings, nucleophilic substitutions, and metal-catalyzed cross-coupling reactions. MSDS and analytical certificates available upon request.

Properties

• CAS Number: 778611-64-6
• Complexity: 99.1
• IUPAC Name: 5-bromo-2-chloro-4-methyl-pyridine
• InChI: InChI=1S/C6H5BrClN/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3
• InChI Key: ISESOOISZHSENQ-UHFFFAOYSA-N
• Exact Mass: 204.92939
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.47
• SMILES: CC1=CC(=NC=C1Br)Cl
• Topological: 12.9
• Monoisotopic Mass: 204.92939
• Synonyms: 5-BROMO-2-CHLORO-4-METHYLPYRIDINE, 778611-64-6, DTXSID50370306, DTXCID40321342, 689-064-4, 5-Bromo-2-chloro-4-picoline, 2-Chloro-4-methyl-5-bromopyridine, MFCD03427663, Pyridine, 5-bromo-2-chloro-4-methyl-, 2-CHLORO-5-BROMO-4-PICOLINE, 2-Chloro-5-bromo-4-methylpyridine, 5-bromo-2-chloro-4-methyl-pyridine, SCHEMBL1007219, ISESOOISZHSENQ-UHFFFAOYSA-N, BCP22091, BBL103065, STL556874, AKOS005145679, AB15095, AC-7004, CS-W015300, HY-W014584, PS-8071, SY018467, 5-Bromo-2-chloro-4-methylpyridine, 97%, DB-023116, B4626, EN300-140786

Application

5-Bromo-2-chloro-4-methylpyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly kinase inhibitors and antiviral agents. Its halogenated pyridine core is valuable for constructing biologically active heterocycles through palladium-catalyzed cross-coupling reactions. Researchers utilize this compound in medicinal chemistry for structure-activity relationship (SAR) studies due to its balanced reactivity profile. The methyl group at the 4-position provides additional opportunities for further derivatization in drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H318 (95.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.6%)
• Eye Dam. 1 (95.2%)

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