Description

2-Fluoro-4-methylbenzoic acid (CAS No. 7697-23-6) is a high-purity fluorinated aromatic carboxylic acid with the molecular formula C₈H₇FO₂. This compound is a valuable building block in organic synthesis, pharmaceutical research, and material science applications. The presence of both fluorine and a carboxylic acid functional group on the aromatic ring makes it a versatile intermediate for further derivatization. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder. Suitable for use in medicinal chemistry, agrochemical development, and as a ligand precursor in coordination chemistry. Packaged under inert gas to ensure stability and shipped with a comprehensive Certificate of Analysis.

Properties

• CAS Number: 7697-23-6
• Complexity: 158
• IUPAC Name: 2-fluoro-4-methyl-benzoic acid
• InChI: InChI=1S/C8H7FO2/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11)
• InChI Key: ALFWHEYHCZRVLO-UHFFFAOYSA-N
• Exact Mass: 154.04300762
• Molecular Formula: C8H7FO2
• Molecular Weight: 154.14
• SMILES: CC1=CC(=C(C=C1)C(=O)O)F
• Topological: 37.3
• Monoisotopic Mass: 154.04300762
• Synonyms: 2-Fluoro-4-methylbenzoic acid, 7697-23-6, DTXSID40371160, DTXCID60322194, 630-126-7, MFCD03092906, 2-fluoro-4-methyl-benzoic Acid, 2-Fluoro-p-toluic Acid, BENZOIC ACID, 2-FLUORO-4-METHYL-, 2-Fluoro-4-methylbenzoicacid, 4-Carboxy-3-fluorotoluene, 2-METHY-5-FLUORO BENZONITRILE, SCHEMBL489010, 4-Methyl-2-fluorobenzoic acid, SCHEMBL3403320, BCP09722, BBL100459, SBB063274, STL554253, AKOS005254424, AC-3181, CS-W002990, FF64207, FS-2194, BP-10282, SY004352, 2-Fluoro-4-methylbenzoic acid, AldrichCPR, DB-005241, F0813, EN300-97224, Z732710382

Application

2-Fluoro-4-methylbenzoic acid serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of non-steroidal anti-inflammatory drugs (NSAIDs) and antimicrobial agents. The fluorine substitution enhances metabolic stability and bioavailability in drug candidates. Researchers utilize this compound in Suzuki-Miyaura coupling reactions to create biaryl structures for material science applications. It also finds use as a precursor for liquid crystal materials and advanced organic electronic compounds.

Safety and Hazards

GHS Hazard Statements

• H302 (81.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (81.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (95.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.