Description

2-Chloroanisole (CAS 766-51-8) is a high-purity aromatic compound with the molecular formula C₇H₇ClO, widely utilized in organic synthesis and specialty chemical applications. This clear to pale yellow liquid, also known as 1-chloro-2-methoxybenzene, exhibits a characteristic aromatic odor and is soluble in organic solvents such as ethanol and ether. With a boiling point of approximately 196-198°C and a molecular weight of 142.58 g/mol, it serves as a versatile intermediate in pharmaceuticals, agrochemicals, and fragrance industries. Our product is rigorously tested for purity (typically ≥98% by GC) and is supplied in sealed amber glass bottles to ensure stability. Ideal for researchers requiring precise electrophilic substitution reactions or methoxy-group modifications in benzene derivatives.

Properties

• CAS Number: 766-51-8
• Complexity: 85
• IUPAC Name: 1-chloro-2-methoxy-benzene
• InChI: InChI=1S/C7H7ClO/c1-9-7-5-3-2-4-6(7)8/h2-5H,1H3
• InChI Key: QGRPVMLBTFGQDQ-UHFFFAOYSA-N
• Exact Mass: 142.0185425
• Molecular Formula: C7H7ClO
• Molecular Weight: 142.58
• SMILES: COC1=CC=CC=C1Cl
• Topological: 9.2
• Monoisotopic Mass: 142.0185425
• Synonyms: 2-Chloroanisole, O-CHLOROANISOLE, Benzene, 1-chloro-2-methoxy-, ortho-Chloroanisole, EINECS 212-167-9, DTXSID1061104, DTXCID0047903, 212-167-9, qgrpvmlbtfgqdq-uhfffaoysa-n, 766-51-8, 1-Chloro-2-methoxybenzene, 1-chloro-2-methoxy-benzene, Anisole, o-chloro-, o-Chloromethoxybenzene, o-Chlorophenyl methyl ether, 2-Chlorophenol methyl ether, chloroanisole, MFCD00000557, NSC 155175, NSC-155175, orthochloroanisole, 2-chloro-anisole, 2-anisolyl chloride, o-methoxyphenyl chloride, 2-Chloroanisole, 98%, E2QJ8FL2ZY, 1-methoxy-2-chlorobenzene, 2-chloro-1-methoxybenzene, SCHEMBL8764, SCHEMBL12541, SCHEMBL95795, SCHEMBL164522, SCHEMBL315016, SCHEMBL514060, SCHEMBL6715609, SCHEMBL13322142, SCHEMBL15051664, NSC155175, SBB060957, AKOS000121948, CS-W018270, FC67417, SY026857, 2-Chloroanisole;1-Chloro-2-methoxybenzene, DB-023501, NS00037825, ST50823836, EN300-31365, W16689, SR-03000001159-1

Application

2-Chloroanisole is primarily employed as a key intermediate in the synthesis of advanced organic compounds, including pharmaceutical ingredients and agrochemicals. It functions as a precursor in the production of dyes, fragrances, and liquid crystal materials due to its reactive chloro and methoxy functional groups. Researchers also utilize it in palladium-catalyzed coupling reactions for constructing complex aromatic frameworks. Its stability under acidic conditions makes it suitable for electrophilic aromatic substitution studies in academic and industrial laboratories.

Safety and Hazards

GHS Hazard Statements

• H227 (20%): Combustible liquid [Warning Flammable liquids]
• H302 (80%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (80%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (20%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (80%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (20%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 4 (20%)
• Acute Tox. 4 (80%)
• Acute Tox. 4 (80%)
• Skin Irrit. 2 (20%)
• Eye Irrit. 2A (20%)
• Acute Tox. 4 (80%)
• STOT SE 3 (20%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.