Description

2,3-Difluorobenzyl Alcohol (CAS No. 75853-18-8) is a high-purity fluorinated aromatic alcohol with the molecular formula C₇H₆F₂O. This compound, also known by its IUPAC name (2,3-difluorophenyl)methanol, is a versatile building block in organic synthesis and pharmaceutical research. Its unique fluorinated structure enhances reactivity and bioavailability, making it valuable for designing advanced materials and bioactive molecules.

Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed containers under inert conditions to maintain stability. Ideal for researchers in medicinal chemistry, agrochemical development, and material science, this compound offers excellent solubility in common organic solvents like DMSO, methanol, and dichloromethane.

Key applications include use as a precursor for fluorinated liquid crystals, pharmaceutical intermediates, and ligands in catalysis. Each batch is accompanied by comprehensive analytical data (NMR, HPLC, MS) to guarantee reproducibility for your sensitive experiments.

Properties

• CAS Number: 75853-18-8
• Complexity: 108
• IUPAC Name: (2,3-difluorophenyl)methanol
• InChI: InChI=1S/C7H6F2O/c8-6-3-1-2-5(4-10)7(6)9/h1-3,10H,4H2
• InChI Key: JSFGDUIJQWWBGY-UHFFFAOYSA-N
• Exact Mass: 144.03867113
• Molecular Formula: C7H6F2O
• Molecular Weight: 144.12
• SMILES: C1=CC(=C(C(=C1)F)F)CO
• Topological: 20.2
• Monoisotopic Mass: 144.03867113
• Synonyms: 2,3-Difluorobenzyl alcohol, 75853-18-8, (2,3-Difluorophenyl)methanol, Benzenemethanol, 2,3-difluoro-, 2,3-Difluorobenzenemethanol, I14VR7T96O, CHEBI:41883, UNII-I14VR7T96O, DTXSID70332244, 23-Difluorobenzyl alcohol, DTXCID20283338, 625-951-4, 922-760-0, jsfgduijqwwbgy-uhfffaoysa-n, 2,3-difluorobenzylalcohol, MFCD00010312, (2,3-difluorophenyl)methan-1-ol, SBB063662, 2,3-Difluorophenylalcohol, 2,3-diflorobenzyl alcohol, bmse000729, (2,3difluorophenyl)methanol, (2,3 difluorophenyl)methanol, SCHEMBL112270, SCHEMBL424618, (2,3-difluoro-phenyl)methanol, SCHEMBL6873275, CHEMBL1232182, SCHEMBL20486385, (2,3-difluoro-phenyl)-methanol, (2,3-Difluorophenyl)methanol #, 2,3-Difluorobenzyl alcohol, 94%, 2,3-Difluorobenzyl alcohol, 97%, ALBB-030139, BCP27032, AKOS005258057, AG-H-02458, CS-W016400, DB04312, PS-8982, AC-23889, PD006317, SY016931, DB-019740, D4619, NS00068294, ST50823888, Q27095131

Application

2,3-Difluorobenzyl Alcohol serves as a critical intermediate in synthesizing fluorinated pharmaceuticals, particularly kinase inhibitors and CNS-active compounds. Its benzyl alcohol moiety allows straightforward derivatization into esters, ethers, or halides for structure-activity relationship studies. The electron-withdrawing fluorine atoms enhance metabolic stability in drug candidates while modulating intermolecular interactions in liquid crystal displays (LCDs). Researchers also utilize it to develop novel fluorinated ligands for asymmetric catalysis.

Safety and Hazards

GHS Hazard Statements

• H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (86.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P280, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P332+P317, P337+P317, and P362+P364

Hazard Classes and Categories

• Skin Irrit. 2 (11.1%)
• Eye Dam. 1 (86.7%)
• Eye Irrit. 2 (11.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.