Description

1,3-Dioxoisoindolin-2-yl 2-(thiophen-2-yl)acetate (CAS No. 752204-15-2) is a high-purity organic compound with the molecular formula C₁₄H₉NO₄S. This specialized chemical features a unique structural combination of a phthalimide (1,3-dioxoisoindolin-2-yl) core and a thiophene-acetate moiety, making it a valuable intermediate for pharmaceutical, agrochemical, and materials science research. The compound is supplied as a crystalline solid with >95% purity (HPLC), ensuring consistency for synthetic applications. Its IUPAC name is (1,3-dioxoisoindol-2-yl) 2-thiophen-2-ylacetate, and it is characterized by excellent stability under standard laboratory conditions. Researchers utilize this compound for developing novel heterocyclic systems, probing structure-activity relationships, and as a building block for bioactive molecule synthesis. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain product integrity.

Properties

• CAS Number: 752204-15-2
• Complexity: 415
• IUPAC Name: (1,3-dioxoisoindolin-2-yl) 2-(2-thienyl)acetate
• InChI: InChI=1S/C14H9NO4S/c16-12(8-9-4-3-7-20-9)19-15-13(17)10-5-1-2-6-11(10)14(15)18/h1-7H,8H2
• InChI Key: OHPAIYCTZCGLNE-UHFFFAOYSA-N
• Exact Mass: 287.02522894
• Molecular Formula: C14H9NO4S
• Molecular Weight: 287.29
• SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)OC(=O)CC3=CC=CS3
• Topological: 91.9
• Monoisotopic Mass: 287.02522894
• Synonyms: 1,3-Dioxoisoindolin-2-yl 2-(thiophen-2-yl)acetate, 752204-15-2, SCHEMBL14191010, H41874, EN300-6513314, 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-(thiophen-2-yl)acetate

Application

This compound serves as a versatile synthon in medicinal chemistry for the development of thiophene-containing pharmacophores, particularly in kinase inhibitor research. It finds application as a key intermediate in the synthesis of potential anticancer and anti-inflammatory agents due to its dual functional group reactivity. Materials scientists employ it for constructing organic electronic materials with enhanced charge transport properties.

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