Description

N2-Trityl Olmesartan Acid (CAS No. 752179-89-8) is a high-purity synthetic intermediate primarily used in pharmaceutical research and development. With the molecular formula C₄₃H₄₀N₆O₃, this compound features a complex structure integrating a trityl-protected tetrazole moiety and an imidazole-carboxylic acid backbone. Its IUPAC name, 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid, highlights its role as a derivative of Olmesartan, a prominent angiotensin II receptor blocker (ARB). This product is rigorously characterized by HPLC, NMR, and mass spectrometry to ensure ≥95% purity, making it ideal for synthetic chemistry applications, drug discovery, and analytical reference standards. Packaged under inert conditions to ensure stability, it is supplied in amber vials with certificates of analysis.

Properties

• CAS Number: 752179-89-8
• Complexity: 1080
• IUPAC Name: 5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
• InChI: InChI=1S/C43H40N6O3/c1-4-16-37-44-39(42(2,3)52)38(41(50)51)48(37)29-30-25-27-31(28-26-30)35-23-14-15-24-36(35)40-45-47-49(46-40)43(32-17-8-5-9-18-32,33-19-10-6-11-20-33)34-21-12-7-13-22-34/h5-15,17-28,52H,4,16,29H2,1-3H3,(H,50,51)
• InChI Key: ITUFJDFACFQQAZ-UHFFFAOYSA-N
• Exact Mass: 688.31618916
• Molecular Formula: C43H40N6O3
• Molecular Weight: 688.8
• SMILES: CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN(N=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)C(=O)O)C(C)(C)O
• Topological: 119
• Monoisotopic Mass: 688.31618916
• Synonyms: 752179-89-8, N2-Trityl Olmesartan Acid, 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(2-trityl-2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid, 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid, 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2′-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-; 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (N2-Tritylolmesartan), SCHEMBL991977

Application

N2-Trityl Olmesartan Acid serves as a critical intermediate in the synthesis of Olmesartan medoxomil, a widely prescribed antihypertensive drug. Researchers utilize this compound to study structure-activity relationships (SAR) in angiotensin II receptor antagonists. It is also employed in protecting-group strategies during peptide and heterocycle synthesis. The trityl group enhances solubility and facilitates selective deprotection in multistep reactions.

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