Description

N-(3,5-Dinitrobenzoyl)-DL-leucine (CAS No. 74928-54-4) is a high-purity chiral derivatizing agent widely used in analytical chemistry and pharmaceutical research. With the molecular formula C₁₃H₁₅N₃O₇ and IUPAC name 2-[(3,5-dinitrobenzoyl)amino]-4-methylpentanoic acid, this compound is specifically designed for the resolution of enantiomers via HPLC or NMR analysis. Its dinitrobenzoyl moiety enhances UV detection sensitivity, making it ideal for trace-level chiral separations. Suitable for research laboratories, this reagent is rigorously tested for consistency and purity, ensuring reliable performance in method development and quality control applications. Store in a cool, dry place away from light to maintain stability.

Properties

• CAS Number: 74928-54-4
• Complexity: 461
• IUPAC Name: 2-[(3,5-dinitrobenzoyl)amino]-4-methyl-pentanoic acid
• InChI: InChI=1S/C13H15N3O7/c1-7(2)3-11(13(18)19)14-12(17)8-4-9(15(20)21)6-10(5-8)16(22)23/h4-7,11H,3H2,1-2H3,(H,14,17)(H,18,19)
• InChI Key: DIOBIOPCRMWGAT-UHFFFAOYSA-N
• Exact Mass: 325.09099983
• Molecular Formula: C13H15N3O7
• Molecular Weight: 325.27
• SMILES: CC(C)CC(C(=O)O)NC(=O)C1=CC(=CC(=C1)[N+](=O)[O-])[N+](=O)[O-]
• Topological: 158
• Monoisotopic Mass: 325.09099983
• Synonyms: N-(3,5-Dinitrobenzoyl)-DL-leucine, 74928-54-4, 624-126-6, Leucine,N-(3,5-dinitrobenzoyl)-, 2-[(3,5-dinitrobenzoyl)amino]-4-methylpentanoic acid, SCHEMBL452263, n-(3,5-dinitrobenzoyl)-s-leucine, NSC401042, AKOS016607202, HY-W142033, NSC-401042, DA-75848, N-(3,5-Dinitrobenzoyl)-DL-leucine, 99%, CS-0201818, ST50997624, 2-[(3,5-dinitrophenyl)carbonylamino]-4-methylpentanoic acid

Application

N-(3,5-Dinitrobenzoyl)-DL-leucine is primarily employed as a chiral derivatizing agent for enantiomeric resolution in HPLC and NMR spectroscopy. It facilitates the separation and quantification of racemic mixtures in pharmaceutical and biochemical research. The compound’s strong UV absorbance makes it valuable for sensitive analytical methods. Researchers also use it to study stereoselective reactions and enzyme specificity.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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