Description

3,5-Difluoropyridine-2-carboxylic acid (CAS No. 745784-04-7) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₃F₂NO₂. This compound is a versatile building block in pharmaceutical and agrochemical research, particularly in the synthesis of active ingredients and intermediates. Its unique structure, featuring two fluorine atoms at the 3- and 5-positions and a carboxylic acid group at the 2-position, enables selective reactivity for cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. Available in ≥98% purity (HPLC), it is supplied as a white to off-white crystalline powder with excellent shelf stability under recommended storage conditions (2-8°C, inert atmosphere). Suitable for use in medicinal chemistry, material science, and as a ligand precursor in catalysis.

Properties

• CAS Number: 745784-04-7
• Complexity: 165
• IUPAC Name: 3,5-difluoropyridine-2-carboxylic acid
• InChI: InChI=1S/C6H3F2NO2/c7-3-1-4(8)5(6(10)11)9-2-3/h1-2H,(H,10,11)
• InChI Key: QKLXAJQKMIWFRC-UHFFFAOYSA-N
• Exact Mass: 159.01318466
• Molecular Formula: C6H3F2NO2
• Molecular Weight: 159.09
• SMILES: C1=C(C=NC(=C1F)C(=O)O)F
• Topological: 50.2
• Monoisotopic Mass: 159.01318466
• Synonyms: 3,5-difluoropyridine-2-carboxylic Acid, 745784-04-7, 676-912-3, 3,5-difluoropicolinic acid, MFCD05664124, 3,5-Difluoro-2-pyridinecarboxylic acid, 2-Pyridinecarboxylic acid, 3,5-difluoro-, 3,5-Difluoropicolinicacid, SCHEMBL107357, DTXSID90382544, QKLXAJQKMIWFRC-UHFFFAOYSA-N, BBL100954, SBB052885, STL554748, AKOS005256446, CS-W007725, PS-6373, SB40501, 3,5-difluoro-pyridine-2-carboxylic acid, SY008959, DB-013517, ST50824726, EN300-98146, 3 pound not5-Difluoropyridine-2-carboxylicacid, 3,5-Difluoropyridine-2-carboxylic acid, 95%, Z1201623169

Application

3,5-Difluoropyridine-2-carboxylic acid is widely employed as a key intermediate in the synthesis of biologically active molecules, including kinase inhibitors and antimicrobial agents. Its fluorinated pyridine core enhances metabolic stability and binding affinity in drug discovery. The carboxylic acid moiety allows for further derivatization via amidation or esterification, making it valuable for peptide mimetics and prodrug development. Researchers also utilize it in metal-organic frameworks (MOFs) and as a ligand in asymmetric catalysis.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.