Description

3-Fluoro-2-methoxybenzaldehyde (CAS No. 74266-68-5) is a high-purity aromatic aldehyde derivative designed for advanced chemical synthesis and pharmaceutical research. With the molecular formula C₈H₇FO₂, this compound features a fluorine substituent at the 3-position and a methoxy group at the 2-position of the benzaldehyde core, offering unique reactivity for electrophilic aromatic substitution and cross-coupling reactions. Ideal for use as a key intermediate in the synthesis of fluorinated drug candidates, agrochemicals, and specialty materials. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed amber vials under inert gas to prevent degradation. Available in quantities ranging from 1g to 1kg with customizable packaging options.

• CAS: 74266-68-5
• Molecular Weight: 154.14 g/mol
• Appearance: Clear to pale yellow liquid
• Storage: 2-8°C under nitrogen

Properties

• CAS Number: 74266-68-5
• Complexity: 138
• IUPAC Name: 3-fluoro-2-methoxy-benzaldehyde
• InChI: InChI=1S/C8H7FO2/c1-11-8-6(5-10)3-2-4-7(8)9/h2-5H,1H3
• InChI Key: UMLOYMZBAUIGKF-UHFFFAOYSA-N
• Exact Mass: 154.04300762
• Molecular Formula: C8H7FO2
• Molecular Weight: 154.14
• SMILES: COC1=C(C=CC=C1F)C=O
• Topological: 26.3
• Monoisotopic Mass: 154.04300762
• Synonyms: 3-FLUORO-2-METHOXYBENZALDEHYDE, 74266-68-5, DTXSID50503016, DTXCID10453826, 676-907-6, 3-Fluoro-2-methoxy-benzaldehyde, 3-FLUORO-2-METHOXYBENZADEHYDE, Benzaldehyde, 3-fluoro-2-methoxy-, MFCD04112486, SCHEMBL680844, SCHEMBL2092150, UMLOYMZBAUIGKF-UHFFFAOYSA-N, CL8324, SBB068761, AKOS006280719, AC-3840, FF67911, AS-15021, DB-005295, CS-0007666, EN300-322944, Z1198164086, 1-Fluoro-3-formyl-2-methoxybenzene. 3-Fluoro-o-anisaldehyde

3-Fluoro-2-methoxybenzaldehyde serves as a versatile building block in medicinal chemistry for the synthesis of fluorinated heterocycles and bioactive molecules. It is particularly valuable in Suzuki-Miyaura couplings and reductive amination reactions to create novel scaffolds for kinase inhibitors or GPCR-targeted compounds. Researchers also utilize it in material science for designing liquid crystals and OLED intermediates due to its electron-withdrawing fluorine moiety.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.