Description

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine (CAS No. 72537-17-8) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₂ClF₄N. This specialized chemical compound is widely utilized in pharmaceutical, agrochemical, and materials science research due to its unique halogenated structure and reactivity. It serves as a versatile building block for synthesizing advanced intermediates, particularly in the development of active pharmaceutical ingredients (APIs) and crop protection agents. Our product is rigorously tested to ensure ≥98% purity (GC), making it ideal for precision applications in organic synthesis, cross-coupling reactions, and nucleophilic substitutions. Available in scalable quantities with comprehensive analytical documentation (GC/MS, NMR, HPLC), this compound is packaged under inert conditions to guarantee stability and longevity.

Properties

• CAS Number: 72537-17-8
• Complexity: 160
• IUPAC Name: 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine
• InChI: InChI=1S/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
• InChI Key: GDSROTVTTLUHCO-UHFFFAOYSA-N
• Exact Mass: 198.9811894
• Molecular Formula: C6H2ClF4N
• Molecular Weight: 199.53
• SMILES: C1=C(C=NC(=C1Cl)F)C(F)(F)F
• Topological: 12.9
• Monoisotopic Mass: 198.9811894
• Synonyms: 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, 72537-17-8, DTXSID40361445, DTXCID60312494, 625-955-6, 3-chloro-2-fluoro-5-trifluoromethylpyridine, MFCD00191918, Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)-, SCHEMBL805963, SBB054395, AKOS006221193, AB04634, CS-W010502, FS-4057, AC-23340, BP-12792, SY033483, DB-055650, C2671, ST51007094, EN300-91517, 3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine, 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, 98%

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is a critical intermediate in the synthesis of fluorinated heterocyclic compounds, particularly in pharmaceutical research for kinase inhibitors and agrochemicals. Its reactive halogen sites enable efficient functionalization via cross-coupling (e.g., Suzuki, Buchwald-Hartwig) or nucleophilic aromatic substitution reactions. The trifluoromethyl group enhances lipophilicity and metabolic stability in drug candidates. Researchers also employ it in material science to develop fluorine-containing liquid crystals or electronic materials.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.