Description

7-Fluoro-2,3-dihydro-1H-indol-2-one (CAS No. 71294-03-6) is a high-purity fluorinated heterocyclic compound with the molecular formula C₈H₆FNO. This specialized chemical, also known as 7-fluorooxindole, is a valuable intermediate in organic synthesis and pharmaceutical research. The compound features a fluoro-substituted indolin-2-one scaffold, making it particularly useful for medicinal chemistry applications. With a molecular weight of 151.14 g/mol, this white to off-white crystalline powder offers excellent solubility in common organic solvents such as DMSO, methanol, and dichloromethane. Our product is rigorously tested to ensure ≥95% purity by HPLC, meeting the stringent requirements of research and industrial applications. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain stability.

Properties

• CAS Number: 71294-03-6
• Complexity: 183
• IUPAC Name: 7-fluoroindolin-2-one
• InChI: InChI=1S/C8H6FNO/c9-6-3-1-2-5-4-7(11)10-8(5)6/h1-3H,4H2,(H,10,11)
• InChI Key: VMUIOEOYZHJLEZ-UHFFFAOYSA-N
• Exact Mass: 151.043341977
• Molecular Formula: C8H6FNO
• Molecular Weight: 151.14
• SMILES: C1C2=C(C(=CC=C2)F)NC1=O
• Topological: 29.1
• Monoisotopic Mass: 151.043341977
• Synonyms: 7-fluoro-1,3-dihydro-2h-indol-2-one, 7-FLUORO-2,3-DIHYDRO-1H-INDOL-2-ONE, 676-237-4, 7-Fluorooxindole, 7-fluoroindolin-2-one, 71294-03-6, 7-fluoro-1,3-dihydroindol-2-one, 7-fluoro-2-oxindole, 7-fluoroindolinone, MFCD02179608, 7-fluoro-1,3-dihydro-indol-2-one, 7-fluoro-oxindole, 2H-Indol-2-one, 7-fluoro-1,3-dihydro-, EC 676-237-4, 7-fluorooxindole, AldrichCPR, SCHEMBL261018, DTXSID90395694, BCP05932, SBB086757, AKOS005063824, AC-6618, CS-W002915, FF12166, FS-2240, SY029301, DB-031763, NS00004417

Application

7-Fluoro-2,3-dihydro-1H-indol-2-one serves as a key building block in the synthesis of biologically active molecules, particularly in the development of kinase inhibitors and CNS-targeting pharmaceuticals. The fluorinated oxindole core structure makes it valuable for creating analogs with enhanced metabolic stability and binding affinity. Researchers utilize this compound in structure-activity relationship (SAR) studies to optimize drug candidates. Its unique electronic properties also make it suitable for materials science applications involving fluorinated organic semiconductors.

Safety and Hazards

GHS Hazard Statements

• H302 (92.9%): Harmful if swallowed [Warning Acute toxicity, oral]

Precautionary Statements

• P264, P270, P301+P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (92.9%)

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