Description

2-Chloro-4-nitrobenzoyl chloride (CAS No. 7073-36-1) is a highly reactive and versatile aromatic acyl chloride derivative with the molecular formula C₇H₃Cl₂NO₃. This compound is characterized by its pale yellow to light brown crystalline appearance and is widely used as a key intermediate in organic synthesis. With its nitro and chloro substituents, it exhibits excellent electrophilic properties, making it ideal for acylation reactions, peptide coupling, and the synthesis of pharmaceuticals, agrochemicals, and dyes. The product is supplied with high purity (>98%) and is rigorously tested for consistency, ensuring optimal performance in research and industrial applications. Proper handling under inert conditions is recommended due to its moisture sensitivity.

Properties

• CAS Number: 7073-36-1
• Complexity: 228
• IUPAC Name: 2-chloro-4-nitro-benzoyl chloride
• InChI: InChI=1S/C7H3Cl2NO3/c8-6-3-4(10(12)13)1-2-5(6)7(9)11/h1-3H
• InChI Key: KTHNITVDTYAHFF-UHFFFAOYSA-N
• Exact Mass: 218.9489983
• Molecular Formula: C7H3Cl2NO3
• Molecular Weight: 220.01
• SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)C(=O)Cl
• Topological: 62.9
• Monoisotopic Mass: 218.9489983
• Synonyms: 2-Chloro-4-nitrobenzoyl chloride, 7073-36-1, Benzoyl chloride, 2-chloro-4-nitro-, EINECS 230-367-4, DTXSID4064559, DTXCID8046791, 230-367-4, 2-chloro-4-nitrobenzoylchloride, 2-chloro-4-nitro-benzoyl chloride, Benzoyl chloride,2-chloro-4-nitro-, MFCD00051515, SCHEMBL752917, AKOS015850048, AS-33122, DB-020840, NS00037107, ST51040129, 2-Chloro-4-nitrobenzoyl chloride, AldrichCPR, EN300-1459121, InChI=1/C7H3Cl2NO3/c8-6-3-4(10(12)13)1-2-5(6)7(9)11/h1-3

Application

2-Chloro-4-nitrobenzoyl chloride is primarily employed as a building block in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. It serves as a precursor for the preparation of amides, esters, and other derivatives through nucleophilic substitution reactions. Researchers also utilize it in the development of dyes, pigments, and agrochemical intermediates due to its reactive benzoyl chloride moiety. Its nitro group further enables participation in reduction and functionalization reactions.

Safety and Hazards

GHS Hazard Statements

• H290 (12.5%): May be corrosive to metals [Warning Corrosive to Metals]
• H314 (87.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (25%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P234, P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P390, P405, P406, and P501

Hazard Classes and Categories

• Met. Corr. 1 (12.5%)
• Skin Corr. 1C (87.5%)
• Eye Dam. 1 (25%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.