Description

Triacetylguanosine (CAS No. 6979-94-8) is a highly purified nucleoside derivative, chemically known as 2′,3′,5′-Tri-O-acetylguanosine. This white to off-white crystalline powder is derived from guanosine through acetylation, resulting in the molecular formula C₁₆H₁₉N₅O₈. With a purity of ≥98%, it is an essential intermediate in organic synthesis, particularly in the production of modified nucleosides for pharmaceutical and biochemical research. Its acetyl-protected ribose moiety enhances stability, making it ideal for oligonucleotide synthesis, antiviral drug development, and as a precursor in nucleotide chemistry. Packaged under inert conditions to ensure longevity, this product is suitable for researchers requiring high-quality, lab-grade reagents.

Properties

• CAS Number: 6979-94-8
• Complexity: 743
• IUPAC Name: [(2R,3R,4R,5R)-3,4-diacetoxy-5-(2-amino-6-oxo-1H-purin-9-yl)tetrahydrofuran-2-yl]methyl acetate
• InChI: InChI=1S/C16H19N5O8/c1-6(22)26-4-9-11(27-7(2)23)12(28-8(3)24)15(29-9)21-5-18-10-13(21)19-16(17)20-14(10)25/h5,9,11-12,15H,4H2,1-3H3,(H3,17,19,20,25)/t9-,11-,12-,15-/m1/s1
• InChI Key: ULXDFYDZZFYGIY-SDBHATRESA-N
• Exact Mass: 409.12336258
• Molecular Formula: C16H19N5O8
• Molecular Weight: 409.35
• SMILES: CC(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=C(NC3=O)N)OC(=O)C)OC(=O)C
• Topological: 173
• Monoisotopic Mass: 409.12336258
• Synonyms: 6979-94-8, 2′,3′,5′-Tri-O-acetylguanosine, Triacetylguanosine, Guanosine, 2′,3′,5′-triacetate, Guanosine Triacetate, Guanosine 2′,3′,5′-triacetate, ZE9MQP77FG, NSC 66387, EINECS 230-242-4, TRI-O-ACETYLGUANOSINE, DTXSID20220081, NSC-66387, DTXCID20142572, 2′,3′,5′-Tri-O-acetyl Guanosine, [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2-amino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl acetate, ULXDFYDZZFYGIY-SDBHATRESA-, MFCD00057054, [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2-amino-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl acetate, (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate, C16H19N5O8, UNII-ZE9MQP77FG, MLS004491909, SCHEMBL1061027, SCHEMBL1061031, HMS1619N03, 2′,3′,5′-Tri-O-acetyl-guanosine, AKOS001714887, AKOS015961100, AKOS037517256, AC-8696, CS-W011683, NT06136, ALD 85092-6, SMR003288853, 2′,3′,5′-Tri-O-acetylguanosine, 98%, NS00036954, T2692, SR-01000088759, SR-01000088759-1, SR-01000088759-2, Guanosine triacetate;2′,3′,5′-Tri-O-acetyl-D-guanosine, 2-amino-6-hydroxyl-9-(2′,3′,5′-tri-O-acetyl-beta-D-ribofuranosyl)purine, [(2R,3R,4R,5R)-4-acetyloxy-5-(acetyloxymethyl)-2-(2-amino-6-oxo-3H-purin-9-yl)ox, 2 inverted exclamation mark pound not3 inverted exclamation mark pound not5 inverted exclamation mark -Tri-O-acetyl Guanosine

Triacetylguanosine is widely used as a protected form of guanosine in nucleoside synthesis, enabling controlled glycosylation reactions. It serves as a key intermediate in the development of antiviral and anticancer therapeutics, particularly in modifying RNA/DNA analogs. Researchers also utilize it in enzymatic studies and as a reference standard in analytical chemistry. Its stability under acidic conditions makes it valuable for solid-phase oligonucleotide synthesis.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.