Description

6-Aminoindazole (CAS No. 6967-12-0) is a high-purity heterocyclic organic compound with the molecular formula C₇H₇N₃ and IUPAC name 1H-indazol-6-amine. This versatile building block is widely utilized in pharmaceutical research, medicinal chemistry, and agrochemical development due to its indazole core, which is a privileged scaffold in drug discovery. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a fine, off-white to beige crystalline powder. It is stable under recommended storage conditions (2-8°C in a tightly sealed container, protected from light and moisture) and is ideal for nucleophilic substitution reactions, palladium-catalyzed cross-couplings, and other synthetic transformations. Suitable for high-throughput screening (HTS) and combinatorial chemistry applications.

Properties

• CAS Number: 6967-12-0
• Complexity: 126
• IUPAC Name: 1H-indazol-6-amine
• InChI: InChI=1S/C7H7N3/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,8H2,(H,9,10)
• InChI Key: KEJFADGISRFLFO-UHFFFAOYSA-N
• Exact Mass: 133.063997236
• Molecular Formula: C7H7N3
• Molecular Weight: 133.15
• SMILES: C1=CC2=C(C=C1N)NN=C2
• Topological: 54.7
• Monoisotopic Mass: 133.063997236
• Solubility: 18.2 [ug/mL]
• Synonyms: 6-Aminoindazole, 1H-Indazol-6-amine, 6967-12-0, 6-Amino-1H-indazole, 2h-indazol-6-amine, 1H-indazol-6-ylamine, Indazol-6-ylamine, 6-Indazolamine, NSC 68265, EINECS 230-177-1, KN72RH56SR, NSC 208700, BRN 0003216, 1H-INDAZOLE, 6-AMINO-, AI3-52442, NSC-68265, NSC-208700, DTXSID90219962, 4-25-00-02522 (Beilstein Handbook Reference), DTXCID40142453, 973-525-4, 6343-52-8, 6-amino-indazole, 1H-indazole-6-ylamine, MFCD00005696, MLS000069415, CHEMBL594707, SMR000059077, 6-Aminoimidazole, 6-aminoindazol, 6-amino indazole, 6AI, 6-Aminobenzopyrazole, 1H-indazole-6-amine, 1-H-indazol-6-amine, INDAZOL-6-AMINE, Opera_ID_362, 1H-indazol-6-yl-amine, 6-Aminoindazole, 98%, UNII-KN72RH56SR, Oprea1_345131, cid_81423, MLS001424157, BIDD:GT0720, SCHEMBL177260, SCHEMBL993762, SCHEMBL6217817, SCHEMBL9529035, SCHEMBL13423879, SCHEMBL27631905, CHEBI:125574, HMS2052M09, HMS2230F12, HMS3394M09, ALBB-036522, BCP00039, NSC16240, NSC68265, AC-052, BDBM50304149, NSC-16240, NSC208700, SBB002517, STK397879, AKOS000120465, AKOS000268458, AS-8503, CCG-101101, CS-W001975, NC00351, PB18392, NCGC00018101-01, NCGC00018101-02, NCGC00018101-03, DA-04152, PD003165, SY002965, DB-023185, ST4094295, A0798, A9214, CS-0368341, NS00036913, EN300-35027, E85321, AE-562/40205851, Q27216189, F2158-0745, Z104500558, InChI=1/C7H7N3/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,8H2,(H,9,10

Application

6-Aminoindazole serves as a key intermediate in the synthesis of kinase inhibitors, anticancer agents, and other biologically active compounds targeting various disease pathways. Its indazole moiety is frequently incorporated into drug candidates for its ability to modulate protein-protein interactions and enzyme activity. Researchers utilize this compound in the development of novel therapeutic agents for inflammation, oncology, and CNS disorders. It is also employed in material science for the design of fluorescent probes and coordination complexes.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.