Description

5-Bromo-2-chloro-3-nitropyridine (CAS No. 67443-38-3) is a high-purity heterocyclic compound with the molecular formula C₅H₂BrClN₂O₂, widely utilized in pharmaceutical and agrochemical research. This halogenated nitropyridine derivative serves as a versatile building block for synthesizing complex molecules due to its reactive bromo, chloro, and nitro functional groups. Its crystalline form ensures consistent performance in coupling reactions, nucleophilic substitutions, and catalytic transformations. Ideal for medicinal chemistry, this compound is rigorously tested for quality (HPLC, NMR) and supplied in secure, light-resistant packaging to maintain stability. Researchers rely on its precise reactivity for developing novel bioactive compounds and advanced materials.

Properties

• CAS Number: 67443-38-3
• Complexity: 163
• IUPAC Name: 5-bromo-2-chloro-3-nitro-pyridine
• InChI: InChI=1S/C5H2BrClN2O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H
• InChI Key: WWQQPSDIIVXFOX-UHFFFAOYSA-N
• Exact Mass: 235.89882
• Molecular Formula: C5H2BrClN2O2
• Molecular Weight: 237.44
• SMILES: C1=C(C=NC(=C1[N+](=O)[O-])Cl)Br
• Topological: 58.7
• Monoisotopic Mass: 235.89882
• Synonyms: 5-Bromo-2-chloro-3-nitropyridine, 67443-38-3, DTXSID60427113, DTXCID60377947, 675-866-1, 2-Chloro-3-nitro-5-bromopyridine, PYRIDINE, 5-BROMO-2-CHLORO-3-NITRO-, MFCD00222270, 5-Bromo-2-chloro-3-nitro-pyridine, 2-chloro-3-nitro-5-bromo pyridine, 2-Chloro-3-nitro-5-bromopyridine; 5-bromo-2-chloro-3-nitro-pyridine;, SCHEMBL422756, WWQQPSDIIVXFOX-UHFFFAOYSA-N, ALBB-037956, BCP22080, CS-D0810, STR08548, BBL102316, SBB054314, STL556115, AKOS005256422, AC-4546, FB10581, PB14159, PS-4910, 5-Bromo-2-chloro-3-nitropyridine, 97%, HY-75149, SY008967, DB-012241, B3963, EN300-53067

Application

5-Bromo-2-chloro-3-nitropyridine is a key intermediate in the synthesis of pharmaceuticals, particularly for antiviral and anticancer agents. Its reactive sites enable efficient cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex heterocycles. The compound also finds use in agrochemical research for developing crop protection agents with enhanced efficacy.

Safety and Hazards

GHS Hazard Statements

• H301 (89.1%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (89.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (10.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (89.1%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (89.1%)
• Eye Irrit. 2 (10.9%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.