Description

Biotin hydrazide (CAS: 66640-86-6) is a high-purity biochemical reagent widely used in bioconjugation and molecular labeling applications. With the molecular formula C₁₀H₁₈N₄O₂S and IUPAC name 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanehydrazide, this compound features a reactive hydrazide group that enables selective conjugation with aldehydes and ketones. Ideal for researchers in proteomics, glycobiology, and diagnostics, our Biotin hydrazide is rigorously tested for consistency, solubility, and low impurity profiles. Packaged under inert conditions to ensure stability, it is suitable for sensitive applications such as glycan labeling, antibody modification, and affinity chromatography.

Properties

• CAS Number: 66640-86-6
• Complexity: 313
• IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanehydrazide
• InChI: InChI=1S/C10H18N4O2S/c11-14-8(15)4-2-1-3-7-9-6(5-17-7)12-10(16)13-9/h6-7,9H,1-5,11H2,(H,14,15)(H2,12,13,16)/t6-,7-,9-/m0/s1
• InChI Key: KOZWHQPRAOJMBN-ZKWXMUAHSA-N
• Exact Mass: 258.11504700
• Molecular Formula: C10H18N4O2S
• Molecular Weight: 258.34
• SMILES: C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NN)NC(=O)N2
• Topological: 122
• Monoisotopic Mass: 258.11504700
• Synonyms: Biotin hydrazide, 66640-86-6, 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, hydrazide, (3aS-(3aalpha,4beta,6aalpha))-, 613-970-0, (+)-Biotin hydrazide, 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanehydrazide, biotin-hydrazide, (+)-Biotin-hydrazide, MFCD00078532, BD4VQ48JNV, 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-,hydrazide, (3aS,4S,6aR)-, 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanehydrazide, Biotin hydrazide HCl, 5-((3AS,4S,6aR)-2-Oxohexahydro-1H-thieno-[3,4-d]imidazol-4-yl)pentanehydrazide, 5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanehydrazide, Biotin-NHNH2, biotin hydrazone, UNII-BD4VQ48JNV, Probes2_000011, SCHEMBL33865, LCZC2370, CHEMBL4458159, DTXSID50985217, EX-A4437, (+)-Biotin hydrazide;Biotin hydrazide, AKOS016009615, CS-6036, FB15362, AS-74083, BP-22107, HY-100215, B2431, NS00122927, (+)-Biotin hydrazide, >=97% (TLC), powder, 5-(2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanohydrazide, 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, hydrazide, (3aS,4S,6aR)-, 1H-THIENO(3,4-D)IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-, HYDRAZIDE, (3AS-(3A.ALPHA.,4.BETA.,6A.ALPHA.))-

Application

Biotin hydrazide is extensively utilized for biotinylating carbohydrates, glycoproteins, and other biomolecules via hydrazone linkage formation. It serves as a critical tool in glycan profiling and detection, enabling sensitive visualization through streptavidin-biotin interactions. Researchers also employ it for modifying antibodies and probes in ELISA, Western blotting, and flow cytometry. Its compatibility with aqueous buffers and organic solvents makes it versatile for diverse experimental setups.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.