Description

4-Methyl-3-(trifluoromethyl)aniline (CAS No. 65934-74-9) is a high-purity aromatic amine compound with the molecular formula C₈H₈F₃N. This specialized chemical features a trifluoromethyl group and a methyl group positioned ortho and para to the aniline nitrogen, respectively, offering unique electronic and steric properties for advanced synthetic applications. Ideal for researchers in pharmaceuticals, agrochemicals, and materials science, our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed, light-resistant containers to maintain stability. Suitable for use as a building block in heterocyclic synthesis, cross-coupling reactions, and fluorinated compound development. Available in quantities from 1g to 1kg with customizable packaging options.

Properties

• CAS Number: 65934-74-9
• Complexity: 155
• IUPAC Name: 4-methyl-3-(trifluoromethyl)aniline
• InChI: InChI=1S/C8H8F3N/c1-5-2-3-6(12)4-7(5)8(9,10)11/h2-4H,12H2,1H3
• InChI Key: JBCDCYFEJQHTTA-UHFFFAOYSA-N
• Exact Mass: 175.06088375
• Molecular Formula: C8H8F3N
• Molecular Weight: 175.15
• SMILES: CC1=C(C=C(C=C1)N)C(F)(F)F
• Topological: 26
• Monoisotopic Mass: 175.06088375
• Synonyms: 4-Methyl-3-(trifluoromethyl)aniline, 65934-74-9, DTXSID50372224, DTXCID10323257, 626-514-0, 5-AMINO-2-METHYLBENZOTRIFLUORIDE, 4-Methyl-3-trifluoromethylaniline, MFCD01631582, 4-methyl-3-(trifluoromethyl)phenylamine, Benzenamine, 4-methyl-3-(trifluoromethyl)-, 4-METHYL-3-TRIFLUOROMETHYL-PHENYLAMINE, 4-Methyl-5-Trifluoromethylaniline, (4-Methyl-3-trifluoromethylphenyl)amine; 3-Trifluoromethyl-4-methylaniline; 4-Amino-2-trifluoromethyltoluene; 4-Methyl-3-(trifluoromethyl)aniline; 4-Methyl-3-(trifluoromethyl)benzenamine, SCHEMBL171825, SCHEMBL4382521, SCHEMBL25396831, DNLFCUUSOAKKAH-UHFFFAOYSA-N, 4-methyl-3-trifluoromethyl-aniline, CL8446, SBB089012, AKOS001407645, AC-2328, CS-W017462, 4-methyl-3-(trifluoromethyl)benzenamine, AS-17280, SY016125, 4-Methyl-3-(trifluoromethyl)aniline, 98%, DB-011378, A8917, M2659, ST50407367, EN300-24723, Z199532228, 5-Amino-2-methylbenzotrifuoride;4-Methyl-3-trifluoromethylaniline

Application

4-Methyl-3-(trifluoromethyl)aniline serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly for CNS-targeting drugs and anti-inflammatory agents. Its electron-withdrawing trifluoromethyl group enhances reactivity in palladium-catalyzed aminations and Suzuki-Miyaura couplings. The compound is also employed in agrochemical research for developing herbicides with improved metabolic stability. Researchers utilize it to modify material properties in OLEDs and liquid crystals due to its polarizable fluorine atoms.

Safety and Hazards

GHS Hazard Statements

• H302 (13%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (13%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (13%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (89.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (13%)
• Acute Tox. 4 (13%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (13%)
• STOT SE 3 (89.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.