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Atomfair 2-Chloro-3-(trifluoromethyl)pyridine C6H3ClF3N CAS 65753-47-1

2-Chloro-3-(trifluoromethyl)pyridine (CAS No. 65753-47-1) is a high-purity halogenated pyridine derivative with the molecular formula C6H3ClF3N. This compound features a trifluoromethyl group and a chloro substituent on the pyridine ring, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science applications. With a purity of ≥97%, it is supplied as a clear to pale yellow liquid or solid, ensuring consistency for synthetic workflows. Ideal for nucleophilic substitution, cross-coupling reactions, and as a building block for fluorinated heterocycles. Store in a cool, dry place under inert conditions to maintain stability. Available in research and bulk quantities with GC/MS and NMR analytical…

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Description

2-Chloro-3-(trifluoromethyl)pyridine (CAS No. 65753-47-1) is a high-purity halogenated pyridine derivative with the molecular formula C6H3ClF3N. This compound features a trifluoromethyl group and a chloro substituent on the pyridine ring, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science applications. With a purity of ≥97%, it is supplied as a clear to pale yellow liquid or solid, ensuring consistency for synthetic workflows. Ideal for nucleophilic substitution, cross-coupling reactions, and as a building block for fluorinated heterocycles. Store in a cool, dry place under inert conditions to maintain stability. Available in research and bulk quantities with GC/MS and NMR analytical data provided.

Properties

  • CAS Number: 65753-47-1
  • Complexity: 136
  • IUPAC Name: 2-chloro-3-(trifluoromethyl)pyridine
  • InChI: InChI=1S/C6H3ClF3N/c7-5-4(6(8,9)10)2-1-3-11-5/h1-3H
  • InChI Key: RXATZPCCMYMPME-UHFFFAOYSA-N
  • Exact Mass: 180.9906113
  • Molecular Formula: C6H3ClF3N
  • Molecular Weight: 181.54
  • SMILES: C1=CC(=C(N=C1)Cl)C(F)(F)F
  • Topological: 12.9
  • Monoisotopic Mass: 180.9906113
  • Synonyms: 2-Chloro-3-(trifluoromethyl)pyridine, 2-Chloro-3-trifluoromethylpyridine, DTXSID00343464, EC 424-520-6, DTXCID00294543, 424-520-6, 628-932-9, 65753-47-1, MFCD00042223, 3-TRIFLUOROMETHYL-2-CHLOROPYRIDINE, PYRIDINE, 2-CHLORO-3-(TRIFLUOROMETHYL)-, 2-Chloro-3-trifluoro methylpyridine, SCHEMBL120643, SCHEMBL791457, SCHEMBL895449, SCHEMBL8369885, CHEMBL4646571, 2-chloro-3-trifiuoromethylpyridine, 2-chloro-3-trifluoromethyl pyridine, 2-chloro-3-trifluoromethyl-pyridine, BBL027981, CX1232, SBB054305, STL373470, 3-(trifluoromethyl)-2-chloropyridine, 2-chloro-3-(trifluoromethyl)-pyridine, AKOS005063711, AC-2548, CS-W002203, DS-0798, PS-6371, SB52634, 2-chloranyl-3-(trifluoromethyl)pyridine, DB-024199, 2-Chloro-3-(trifluoromethyl)pyridine, 97%, C1193, NS00005164, ST50826655, EN300-21398, A835219, A1-00487, F0001-1757

2-Chloro-3-(trifluoromethyl)pyridine is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals due to its reactive halogen and electron-withdrawing trifluoromethyl group. It serves as a precursor for Suzuki-Miyaura and Buchwald-Hartwig couplings to construct complex heterocyclic scaffolds. Researchers also employ it in the development of fluorinated liquid crystals and corrosion inhibitors. Its stability under acidic conditions makes it suitable for multistep synthetic routes.

Safety and Hazards

GHS Hazard Statements

  • H301: Toxic if swallowed [Danger Acute toxicity, oral]
  • H311: Toxic in contact with skin [Danger Acute toxicity, dermal]
  • H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
  • H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
  • H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

  • P260, P262, P264, P270, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P330, P361+P364, P363, P405, and P501

Hazard Classes and Categories

  • Flam. Sol. 1 (81.2%)
  • Acute Tox. 3 (97.9%)
  • Acute Tox. 3 (16.7%)
  • Skin Corr. 1B (16.7%)
  • Skin Irrit. 2 (83.3%)
  • Eye Irrit. 2 (83.3%)
  • STOT SE 3 (81.2%)
  • STOT RE 1 (14.6%)
  • Aquatic Chronic 3 (16.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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