Description

2,4-Difluorophenylacetonitrile (CAS No. 656-35-9) is a high-purity fluorinated organic compound with the molecular formula C₈H₅F₂N. This versatile intermediate is widely used in pharmaceutical, agrochemical, and materials science research. The compound features a phenyl ring substituted with two fluorine atoms at the 2- and 4-positions, along with an acetonitrile functional group, making it a valuable building block for further synthetic modifications. Our product is rigorously tested to ensure ≥98% purity (by GC/HPLC) and is supplied in sealed containers under inert atmosphere to guarantee stability. Ideal for nucleophilic substitution reactions, cross-coupling chemistry, and as a precursor for heterocyclic compounds. Available in quantities from grams to kilograms with customizable packaging options.

Properties

• CAS Number: 656-35-9
• Complexity: 172
• IUPAC Name: 2-(2,4-difluorophenyl)acetonitrile
• InChI: InChI=1S/C8H5F2N/c9-7-2-1-6(3-4-11)8(10)5-7/h1-2,5H,3H2
• InChI Key: AGAOESUOSOGZOD-UHFFFAOYSA-N
• Exact Mass: 153.03900549
• Molecular Formula: C8H5F2N
• Molecular Weight: 153.13
• SMILES: C1=CC(=C(C=C1F)F)CC#N
• Topological: 23.8
• Monoisotopic Mass: 153.03900549
• Synonyms: 2,4-Difluorophenylacetonitrile, 656-35-9, Benzeneacetonitrile, 2,4-difluoro-, (2,4-Difluorophenyl)acetonitrile, SU758G7CQV, EINECS 211-514-1, 2,4-difluorobenzeneacetonitrile, DTXSID20215856, DTXCID50138347, 211-514-1, 2-(2,4-difluorophenyl)acetonitrile, 2,4-Difluorobenzyl Cyanide, 2,4-Difluorobenzylcyanide, MFCD00009971, 2-(2,4-difluorophenyl)ethanenitrile, UNII-SU758G7CQV, SCHEMBL548158, 2,4-difluorophenyl acetonitrile, AGAOESUOSOGZOD-UHFFFAOYSA-, 2,4-difluoro phenyl acetonitrile, SBB063247, 2,4-Difluorophenylacetonitrile, 97%, AKOS009157905, CS-W018082, PS-8909, AC-24898, SY017087, DB-024193, D3441, NS00042263, ST50824385, EN300-82367, A22698, Z963395642, 2,4-Difluorobenzyl cyanide;2-(2,4-Difluorophenyl)acetonitrile, InChI=1/C8H5F2N/c9-7-2-1-6(3-4-11)8(10)5-7/h1-2,5H,3H2

Application

2,4-Difluorophenylacetonitrile serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly antifungal and antibacterial agents. It is employed in the development of liquid crystal materials and advanced organic electronic components due to its stable fluorinated aromatic structure. Researchers also utilize this nitrile derivative in palladium-catalyzed coupling reactions to construct complex molecular architectures.

Safety and Hazards

GHS Hazard Statements

• H302 (95.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (95.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (95.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (95.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (95.8%)
• Acute Tox. 4 (95.8%)
• Skin Irrit. 2 (97.9%)
• Eye Irrit. 2 (97.9%)
• Acute Tox. 4 (95.8%)
• STOT SE 3 (95.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.