Description

Phenol, 2-fluoro-5-methyl- (CAS No. 63762-79-8) is a high-purity fluorinated phenolic compound with the molecular formula C₇H₇FO. This specialty chemical, also known as 2-fluoro-5-methylphenol, is a valuable building block in organic synthesis and pharmaceutical research. The compound features a fluorine substituent at the ortho position and a methyl group at the meta position relative to the hydroxyl group, offering unique electronic and steric properties for regioselective reactions.

Our product is synthesized under strict quality control measures and is available in various packaging options to suit laboratory-scale and industrial applications. Each batch is thoroughly characterized by GC-MS, HPLC, and ¹H/¹⁹F NMR to ensure >98% purity (typical purity 99% by GC analysis). The compound is supplied as a clear to pale yellow liquid with a characteristic phenolic odor, stored under inert atmosphere to prevent oxidation.

Key applications include use as:

• Precursor for advanced pharmaceutical intermediates
• Ligand in transition metal catalysis
• Building block for liquid crystal materials
• Modifier in polymer chemistry

Safety Information: Corrosive. Causes severe skin burns and eye damage. Handle with appropriate personal protective equipment in a well-ventilated fume hood.

Properties

• CAS Number: 63762-79-8
• Complexity: 94.9
• IUPAC Name: 2-fluoro-5-methyl-phenol
• InChI: InChI=1S/C7H7FO/c1-5-2-3-6(8)7(9)4-5/h2-4,9H,1H3
• InChI Key: XEHPMVZYZDQLDN-UHFFFAOYSA-N
• Exact Mass: 126.048093005
• Molecular Formula: C7H7FO
• Molecular Weight: 126.13
• SMILES: CC1=CC(=C(C=C1)F)O
• Topological: 20.2
• Monoisotopic Mass: 126.048093005
• Synonyms: 2-Fluoro-5-methylphenol, 63762-79-8, phenol, 2-fluoro-5-methyl-, 6-Fluoo-m-cresol, DTXSID10213205, DTXCID70135696, 627-556-2, 2-fluoro-5-methyl-phenol, MFCD00190101, 6-Fluoro-m-cresol, 4-Fluoro-3-hydroxytoluene, 5-Methyl-2-fluorophenol, 2-fluoro-5-methyl phenol, 2-fluoranyl-5-methyl-phenol, SCHEMBL12127, SCHEMBL4390907, SCHEMBL8614617, SCHEMBL27694534, 2-Fluoro-5-methylphenol, 98%, XEHPMVZYZDQLDN-UHFFFAOYSA-N, CL8466, SBB085653, AKOS005259620, CS-W008056, PS-9180, SY020674, DB-024181, ST51038442, EN300-84222, A834515, Z384970734

Application

2-Fluoro-5-methylphenol serves as a versatile intermediate in medicinal chemistry for the synthesis of fluorinated drug candidates, particularly in CNS-active compounds where the fluorine atom enhances blood-brain barrier penetration. The compound finds use in material science as a monomer for specialty polymers with enhanced thermal stability. Researchers also employ this fluorophenol derivative as a probe molecule in studies of hydrogen bonding and aromatic substitution patterns.

Safety and Hazards

GHS Hazard Statements

• H315 (89.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (91.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (91.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (89.1%)
• Eye Irrit. 2 (91.3%)
• STOT SE 3 (91.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.