Atomfair 2-Fluoro-5-methylanisole C8H9FO CAS 63762-78-7

Description

2-Fluoro-5-methylanisole (CAS No. 63762-78-7) is a high-purity fluorinated aromatic compound with the molecular formula C₈H₉FO and IUPAC name 1-fluoro-2-methoxy-4-methylbenzene. This specialty chemical is meticulously synthesized for researchers and industrial scientists requiring precise fluorinated building blocks in organic synthesis, pharmaceuticals, and material science applications. The compound features a fluorine substituent adjacent to a methoxy group on a toluene backbone, offering unique electronic and steric properties for regioselective reactions. Available in >98% purity (GC), it is supplied in sealed amber glass vials under inert atmosphere to ensure stability. Ideal for use in Suzuki couplings, nucleophilic aromatic substitutions, and as a precursor for advanced intermediates. MSDS and NMR/GC-MS analytical data are available upon request.

Properties

• CAS Number: 63762-78-7
• Complexity: 105
• IUPAC Name: 1-fluoro-2-methoxy-4-methyl-benzene
• InChI: InChI=1S/C8H9FO/c1-6-3-4-7(9)8(5-6)10-2/h3-5H,1-2H3
• InChI Key: MOFZLPPSEOEXNJ-UHFFFAOYSA-N
• Exact Mass: 140.063743068
• Molecular Formula: C8H9FO
• Molecular Weight: 140.15
• SMILES: CC1=CC(=C(C=C1)F)OC
• Topological: 9.2
• Monoisotopic Mass: 140.063743068
• Synonyms: 2-Fluoro-5-methylanisole, 63762-78-7, DTXSID50372022, DTXCID10323055, 620-855-9, 1-fluoro-2-methoxy-4-methylbenzene, MFCD00665791, 1-fluoro-2-methoxy-4-methyl-benzene, 4-Fluoro-3-methoxytoluene, Benzene, 1-fluoro-2-methoxy-4-methyl-, SCHEMBL12321, SCHEMBL1099031, SCHEMBL1636803, MOFZLPPSEOEXNJ-UHFFFAOYSA-N, SBB086162, AKOS005257987, FF66505, PS-9035, ST50823676

Application

2-Fluoro-5-methylanisole serves as a versatile intermediate in pharmaceutical research, particularly in the development of fluorinated drug candidates where its electron-withdrawing fluorine enhances metabolic stability. The compound is employed in material science for synthesizing liquid crystals and specialty polymers requiring tuned dielectric properties. Its orthogonal reactivity makes it valuable for constructing complex aromatic systems in agrochemical and OLED material research.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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