Description

2-Chloro-3-hydrazinopyrazine (CAS No. 63286-28-2) is a high-purity heterocyclic compound with the molecular formula C₄H₅ClN₄ and IUPAC name (3-chloropyrazin-2-yl)hydrazine. This specialized chemical is a valuable building block in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and functional materials. Its reactive hydrazine and chloro substituents on the pyrazine ring enable diverse derivatization, making it ideal for nucleophilic substitution, condensation, and cyclization reactions. Our product is rigorously tested to ensure ≥95% purity (HPLC) and is supplied as a crystalline solid with full analytical documentation (MS, NMR, FTIR). Suitable for research-scale and process development applications, it is packaged under inert gas to ensure stability and shipped with proper handling precautions.

Properties

• CAS Number: 63286-28-2
• Complexity: 88.6
• IUPAC Name: (3-chloropyrazin-2-yl)hydrazine
• InChI: InChI=1S/C4H5ClN4/c5-3-4(9-6)8-2-1-7-3/h1-2H,6H2,(H,8,9)
• InChI Key: PUUGNIKJWZNTBK-UHFFFAOYSA-N
• Exact Mass: 144.0202739
• Molecular Formula: C4H5ClN4
• Molecular Weight: 144.56
• SMILES: C1=CN=C(C(=N1)NN)Cl
• Topological: 63.8
• Monoisotopic Mass: 144.0202739
• Synonyms: 2-Chloro-3-hydrazinopyrazine, 640-727-6, 2-chloro-3-hydrazinylpyrazine, 63286-28-2, (3-chloropyrazin-2-yl)hydrazine, 1-(3-chloropyrazin-2-yl)hydrazine, MFCD08272804, 2-(3-CHLOROPYRAZIN-2-YL)HYDRAZINE, 3-Chloro-2(H)-pyrazinone hydrazone, NSC272203, 2(1H)-PYRAZINONE, 3-CHLORO-, HYDRAZONE, 3-chloro-2-hydrazinopyrazine, 2-chloro-3-hydrazineylpyrazine, SCHEMBL1179963, OSM-S-657, DTXSID00313546, 2-Chloro-3-hydrazinopyrazine, 95%, BBL005540, GEO-03685, STL134905, AKOS005745086, CS-W011003, NSC-272203, PB16012, PS-5656, SY031007, EN300-75567, (3-Chloro-pyrazin-2-yl)-hydrazine; hydrochloride

Application

2-Chloro-3-hydrazinopyrazine serves as a key intermediate in medicinal chemistry for synthesizing pyrazine-based drug candidates, particularly kinase inhibitors and antimicrobial agents. Its reactive sites facilitate the construction of fused heterocycles like pyrazolo[1,5-a]pyrazines, valuable scaffolds in drug discovery. The compound is also employed in coordination chemistry for ligand design and in material science for functionalized polymer synthesis.

Safety and Hazards

GHS Hazard Statements

• H301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (95.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (97.6%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (95.1%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.