Description

3-Chloro-1-propanol (CAS No. 627-30-5) is a versatile chlorinated alcohol with the molecular formula C₃H₇ClO and IUPAC name 3-chloropropan-1-ol. This clear, colorless to pale yellow liquid is widely used in organic synthesis, pharmaceutical intermediates, and chemical research. With a molecular weight of 94.54 g/mol, it exhibits a boiling point of 160-162°C and a density of 1.131 g/cm³ at 25°C. Its reactive chloro and hydroxyl groups make it a valuable building block for nucleophilic substitution reactions, esterifications, and cyclizations. Packaged in high-quality amber glass bottles or chemical-resistant containers to ensure stability and purity (typically ≥98% by GC). Suitable for laboratory and industrial applications under controlled conditions. Handle with proper PPE due to potential skin/eye irritation.

Properties

• CAS Number: 627-30-5
• Complexity: 16.4
• IUPAC Name: 3-chloropropan-1-ol
• InChI: InChI=1S/C3H7ClO/c4-2-1-3-5/h5H,1-3H2
• InChI Key: LAMUXTNQCICZQX-UHFFFAOYSA-N
• Exact Mass: 94.0185425
• Molecular Formula: C3H7ClO
• Molecular Weight: 94.54
• SMILES: C(CO)CCl
• Topological: 20.2
• Monoisotopic Mass: 94.0185425
• Physical Description: 3-chloropropanol-1 appears as a colorless liquid with a mild odor. Slightly denser than water. Toxic by ingestion and inhalation. Flash point 270 °F. Used to make plastics, resins and other chemicals.
• Boiling Point: 320 to 329 °F at 760 mmHg
• Flash Point: 164 °F
• Solubility: 50 to 100 mg/mL at 73 °F
• Density: 1.13 to 1.15 at 68 °F
• Vapor Pressure: 1.2 [mmHg]
• Synonyms: 3-CHLORO-1-PROPANOL, 3-Chloropropan-1-ol, 627-30-5, 3-Chloropropanol, Trimethylene chlorohydrin, 1-Propanol, 3-chloro-, 3-Chlorpropan-1-ol, 3-Choro-1-propanol, 1-Chloro-3-propanol, 3-Chloropropanol-1, NSC 60190, 3-Chlorpropan-1-ol [German], CCRIS 4767, 3-Chloro-1-hydroxypropane, EINECS 210-992-9, UN2849, BRN 0773655, DTXSID9024809, AI3-61821, NSC-60190, DTXCID604809, 148011U61G, CHLORO-1-PROPANOL, 3-, 4-01-00-01441 (Beilstein Handbook Reference), 3-chloropropyl alcohol, 3chloropropanol, 3Chlorpropan1ol, 1Chloro3propanol, 3Chloropropanol1, Chloro3 propanol1, 1Propanol, 3chloro, 3Chloropropyl alcohol, 1Chloro3hydroxypropane, 3Chloro1hydroxypropane, Chloropropanol, 3, 1, Chloro3 propanol1 (French DOT), 210-992-9, inchi=1/c3h7clo/c4-2-1-3-5/h5h,1-3h, 1-Chloro-3-hydroxypropane, 3-chloro-propan-1-ol, 3-Chloro-l-propanol, 28064-81-5, Propanol, chloro-, MFCD00002943, 3-chloro-propanol, UNII-148011U61G, 3-chloro-1 propanol, Propanol, 3-chloro-, 3-Chloropropane-1-ol, 3-chloranylpropan-1-ol, trimethylene chlorohydrine, SCHEMBL19178, SCHEMBL98331, SCHEMBL700904, SCHEMBL891532, 3-Chloro-1-propanol, 98%, SCHEMBL2474868, SCHEMBL5176904, CHEMBL1230102, NSC60190, STR03655, Tox21_303962, AKOS000121342, FC38664, UN 2849, NCGC00357193-01, 3CL, CAS-627-30-5, 3-Chloropropanol-1 [UN2849] [Poison], NS00022565, EN300-22342, E78849, A833956, 3-Chloro-1-propanol 100 microg/mL in Acetonitrile, Q27251597, F0001-1685

Application

3-Chloro-1-propanol serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It is utilized in the production of propylene oxide derivatives and as a precursor for quaternary ammonium compounds. Researchers employ it in heterocyclic chemistry to construct pyrrolidine and other nitrogen-containing rings. Its bifunctional reactivity also enables applications in polymer modification and crosslinking agents.

Safety and Hazards

GHS Hazard Statements

• H302 (22.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (54.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (60.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (57.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (22.9%)
• Skin Irrit. 2 (54.2%)
• Eye Irrit. 2 (60.8%)
• STOT SE 3 (57.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.