Description

3-Bromopyridine (CAS 626-55-1) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₄BrN. This versatile heterocyclic compound is widely utilized in pharmaceutical, agrochemical, and material science research due to its reactive bromine substituent at the 3-position of the pyridine ring. Our product is supplied as a clear to pale yellow liquid with a purity of ≥99%, ensuring optimal performance in coupling reactions, metal-catalyzed cross-couplings (such as Suzuki or Stille reactions), and as a building block for complex molecular architectures. The compound is packaged under inert atmosphere to maintain stability and comes with comprehensive analytical documentation including GC/MS, NMR, and HPLC spectra for quality verification. Proper handling precautions are required due to its lachrymatory properties and potential skin/eye irritation.

Properties

• CAS Number: 626-55-1
• Complexity: 56
• IUPAC Name: 3-bromopyridine
• InChI: InChI=1S/C5H4BrN/c6-5-2-1-3-7-4-5/h1-4H
• InChI Key: NYPYPOZNGOXYSU-UHFFFAOYSA-N
• Exact Mass: 156.95271
• Molecular Formula: C5H4BrN
• Molecular Weight: 158.00
• SMILES: C1=CC(=CN=C1)Br
• Topological: 12.9
• Monoisotopic Mass: 156.95271
• Physical Description: Liquid
• Flash Point: 51 °C
• Vapor Pressure: 1.75 [mmHg]
• Synonyms: 3-BROMOPYRIDINE, 3-pyridyl bromide, Pyridine, 3-bromo-, 5-bromopyridine, 3-bromo pyridine, m-bromopyridine, UNII-XMN8H2XE9H, XMN8H2XE9H, NSC 3974, NSC-3974, EINECS 210-952-0, PYRIDIN-3-YL BROMIDE, AI3-17853, DTXSID9060819, CHEBI:51575, Pyridine, 3bromo, DTXCID1043417, 210-952-0, inchi=1/c5h4brn/c6-5-2-1-3-7-4-5/h1-4, nypypozngoxysu-uhfffaoysa-n, 626-55-1, 3-bromo-pyridine, MFCD00006373, CHEMBL5396433, C5H4BrN, 3-bromopryidine, 3-bromopyridin, 3-Pyridyl Bromide; NSC 3974; Pyridin-3-yl Bromide; m-Bromopyridine;, 5-bromo-pyridine, 3-Bromopyridine, 99%, SCHEMBL6350, SCHEMBL207286, SCHEMBL208398, SCHEMBL317518, SCHEMBL449058, SCHEMBL6205331, NSC3974, BCP22223, RCA14814, STR04425, BBL027581, BDBM50622787, CX1091, SBB003998, STK802249, AKOS000119193, AB00739, FB05462, PS-4257, BP-13125, DB-027636, DB-348461, B0651, CS-0008362, NS00035120, ST51038546, EN300-19110, Q223057, F0001-1682

3-Bromopyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and antiviral compounds. In material science, it is employed as a precursor for conductive polymers and liquid crystal materials. The compound’s reactivity makes it valuable for palladium-catalyzed cross-coupling reactions to create bipyridine ligands and other nitrogen-containing heterocycles. Researchers also utilize it as a derivatization agent in analytical chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H226 (93.3%): Flammable liquid and vapor [Warning Flammable liquids]
• H301 (11.7%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (86.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (18.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (98.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (11.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (95%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (93.3%)
• Acute Tox. 3 (11.7%)
• Acute Tox. 4 (86.7%)
• Acute Tox. 3 (18.3%)
• Skin Irrit. 2 (98.3%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (11.7%)
• STOT SE 3 (95%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.