Description

Ethyl Glycolate (CAS 623-50-7) is a high-purity organic ester with the molecular formula C₄H₈O₃, widely utilized in pharmaceutical synthesis, fragrance formulation, and specialty chemical applications. This clear, colorless to pale yellow liquid (IUPAC name: ethyl 2-hydroxyacetate) exhibits excellent solvency properties with a characteristic mild odor. Our premium-grade Ethyl Glycolate is rigorously tested to meet stringent quality standards, ensuring batch-to-batch consistency for research and industrial applications. With a purity of ≥98% (GC), this versatile building block is particularly valuable for esterification reactions and as a precursor in polymer chemistry. Proper storage in tightly sealed containers under inert atmosphere at 2-8°C is recommended to maintain optimal stability.

Properties

• CAS Number: 623-50-7
• Complexity: 60
• IUPAC Name: ethyl 2-hydroxyacetate
• InChI: InChI=1S/C4H8O3/c1-2-7-4(6)3-5/h5H,2-3H2,1H3
• InChI Key: ZANNOFHADGWOLI-UHFFFAOYSA-N
• Exact Mass: 104.047344113
• Molecular Formula: C4H8O3
• Molecular Weight: 104.10
• SMILES: CCOC(=O)CO
• Topological: 46.5
• Monoisotopic Mass: 104.047344113
• Physical Description: Clear colorless liquid;
• Synonyms: Ethyl glycolate, 623-50-7, Ethyl hydroxyacetate, Ethyl glycollate, GLYCOLIC ACID, ETHYL ESTER, Hydroxyacetic acid ethyl ester, Acetic acid, 2-hydroxy-, ethyl ester, NSC 8835, EINECS 210-798-4, BRN 1743766, C306E91WFK, AI3-03541, NSC-8835, 4-03-00-00580 (Beilstein Handbook Reference), Acetic acid, hydroxy, ethyl ester, Acetic acid, 2hydroxy, ethyl ester, ethyl 2-hydroxyacetate, Acetic acid, hydroxy-, ethyl ester, MFCD00021970, Glycolic Acid Ethyl Ester, UNII-C306E91WFK, ethyl-hydroxyacetate, Ethyl 2-Hydroxyacetate; Ethyl Hydroxyacetate; Glycolic Acid Ethyl Ester; 2-Hydroxyacetic Acid Ethyl Ester; NSC 8835, Ethyl glycolate, 98%, HOCH2COOC2H5, SCHEMBL5074, SCHEMBL5075, hydroxyacetic acid ethylester, WLN: Q1VO2, hydroxy acetic acid ethyl ester, hydroxy-acetic acid ethyl ester, SCHEMBL2440571, SCHEMBL2690186, SCHEMBL2690187, SCHEMBL8069406, SCHEMBL9538110, DTXSID5060772, ZANNOFHADGWOLI-UHFFFAOYSA-, NSC8835, 2-hydroxy-acetic acid ethyl ester, AKOS009157950, CS-W019892, AS-17295, BP-21252, SY002762, DB-001024, G0242, NS00022536, EN300-42326, Q27275115, F0001-1672, Z385458066, InChI=1/C4H8O3/c1-2-7-4(6)3-5/h5H,2-3H2,1H3

Application

Ethyl Glycolate serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly in prodrug development. In the fragrance industry, it functions as a mild fruity-ester modifier for floral and berry accords. The compound finds additional utility as a reactive diluent in specialty polymer formulations and as a solvent for cellulose derivatives. Researchers value its bifunctional (hydroxyl and ester) reactivity for controlled esterification processes.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.