Description

3-Nitrobenzyl alcohol (CAS 619-25-0) is a high-purity aromatic alcohol derivative with the molecular formula C₇H₇NO₃. This compound, also known as (3-nitrophenyl)methanol, features a nitro group meta-substituted on the benzyl alcohol backbone, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its crystalline solid form and solubility in common organic solvents like ethanol and DMSO ensure versatile handling for laboratory applications. Ideal for use as a reagent in nucleophilic substitution reactions, protecting group strategies, and as a precursor for nitroaromatic transformations. Each batch is rigorously tested via GC/MS and HPLC to guarantee ≥98% purity, meeting the stringent requirements of research and industrial applications.

Properties

• CAS Number: 619-25-0
• Complexity: 143
• IUPAC Name: (3-nitrophenyl)methanol
• InChI: InChI=1S/C7H7NO3/c9-5-6-2-1-3-7(4-6)8(10)11/h1-4,9H,5H2
• InChI Key: CWNPOQFCIIFQDM-UHFFFAOYSA-N
• Exact Mass: 153.042593085
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.14
• SMILES: C1=CC(=CC(=C1)[N+](=O)[O-])CO
• Topological: 66.1
• Monoisotopic Mass: 153.042593085
• Physical Description: Liquid; mp = 30-32 deg C;
• Vapor Pressure: 0.0000858 [mmHg]
• Synonyms: 3-Nitrobenzyl alcohol, 619-25-0, (3-Nitrophenyl)methanol, m-Nitrobenzyl alcohol, Benzenemethanol, 3-nitro-, 3-Nitrobenzenemethanol, Benzyl alcohol, m-nitro-, CCRIS 7971, NSC 5388, EINECS 210-588-2, BRN 2044769, AI3-04242, F829X990IV, NSC-5388, M-NITROPHENYLMETHANOL, DTXSID0060698, NITROBENZYL ALCOHOL, 3-, 4-06-00-02609 (Beilstein Handbook Reference), M-(HYDROXYMETHYL)NITROBENZENE, mNitrobenzyl alcohol, 3Nitrobenzenemethanol, Benzyl alcohol, mnitro, Benzenemethanol, 3nitro, DTXCID1043170, 210-588-2, 3-nitrobenzylalcohol, MFCD00007273, (3-nitrophenyl)methan-1-ol, UNII-F829X990IV, m-nitrobenzylalcohol, 3-nitro-benzylalcohol, m-Nitro-benzyl alcohol, meta-nitrobenzyl alcohol, (3-Nitro-phenyl)-methanol, (3-Nitrophenyl)methanol #, SCHEMBL94845, SCHEMBL94846, 3-Nitrobenzyl alcohol, 98%, SCHEMBL129430, SCHEMBL6206141, SCHEMBL7304803, (3-Nitrophenyl)methanol; NOBA, SCHEMBL16956911, SCHEMBL17347330, NSC5388, CHEBI:191016, SBB058555, AKOS009097886, FN33824, PS-5310, AC-10907, SY005331, DB-016020, CS-0096804, N0178, NS00034848, ST51028316, EN300-59045, A10311, Q414170, 3-Nitrobenzyl alcohol, for mass spectrometry, >=99.5%, Z425721958, 3-Nitrobenzyl alcohol [Matrix for FABMS and liquid SIMS], InChI=1/C7H7NO3/c9-5-6-2-1-3-7(4-6)8(10)11/h1-4,9H,5H

Application

3-Nitrobenzyl alcohol serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. Its nitro group enhances reactivity in electrophilic aromatic substitution reactions, facilitating the production of complex aromatic compounds. Researchers utilize it as a protecting group for alcohols in multi-step organic syntheses. In material science, it acts as a monomer for nitro-functionalized polymers. Additionally, its derivatives are explored in antimicrobial and anticancer agent development.

Safety and Hazards

GHS Hazard Statements

• H302 (28.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (14.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (85.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (85.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (28.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (28.6%)
• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (85.7%)
• Eye Irrit. 2A (85.7%)
• Acute Tox. 4 (28.6%)
• STOT SE 3 (85.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.