Description

N-(2-Bromo-4-methylphenyl)acetamide (CAS No. 614-83-5) is a high-purity brominated aromatic acetamide compound with the molecular formula C₉H₁₀BrNO. This specialized organic intermediate is widely utilized in pharmaceutical research, agrochemical synthesis, and advanced material development. The compound features a bromine substituent at the ortho position and a methyl group at the para position relative to the acetamide functionality, making it a valuable scaffold for further derivatization. Available in >98% purity by HPLC, this product is supplied as a white to off-white crystalline powder with strict quality control to ensure batch-to-batch consistency. Ideal for Suzuki coupling reactions, palladium-catalyzed transformations, and as a building block in medicinal chemistry. Packaged under inert atmosphere in amber glass vials to ensure stability during storage and shipping.

Properties

• CAS Number: 614-83-5
• Complexity: 172
• IUPAC Name: N-(2-bromo-4-methyl-phenyl)acetamide
• InChI: InChI=1S/C9H10BrNO/c1-6-3-4-9(8(10)5-6)11-7(2)12/h3-5H,1-2H3,(H,11,12)
• InChI Key: UUDGTWKIIUEVJD-UHFFFAOYSA-N
• Exact Mass: 226.99458
• Molecular Formula: C9H10BrNO
• Molecular Weight: 228.09
• SMILES: CC1=CC(=C(C=C1)NC(=O)C)Br
• Topological: 29.1
• Monoisotopic Mass: 226.99458
• Synonyms: 614-83-5, N-(2-Bromo-4-methylphenyl)acetamide, 2′-Bromo-4′-methylacetanilide, Acetamide, N-(2-bromo-4-methylphenyl)-, NSC 8063, DTXSID6060636, DTXCID8043028, 612-156-2, 2-Bromo-4-methylacetanilide, MFCD00017781, 9J7X4GFM5M, NSC-8063, N-Acetyl-2-bromo-p-toluidine, NSC8063, 2′-Bromo-p-acetotoluidide, UNII-9J7X4GFM5M, 4-Acetamido-3-bromotoluene, Cambridge id 5104354, 4-Acetamino-3-bromo-toluene, CBDivE_001966, 2-bromo-4-methyl acetanilide, SCHEMBL420721, UUDGTWKIIUEVJD-UHFFFAOYSA-, ALBB-036635, AKOS000183098, N-(2-bromo-4-methyl-phenyl)acetamide, 2′-Bromo-4′-methylacetanilide, 98%, N-(2-bromo-4-methyl-phenyl)-acetamide, 2′-BROMO-4′-METHYLACETANILIDE, AS-36549, SY049180, DB-053903, B0125, CS-0187538, NS00034701, ST50320186, AG-668/02843010, SR-01000195226, SR-01000195226-1, Z26522737, InChI=1/C9H10BrNO/c1-6-3-4-9(8(10)5-6)11-7(2)12/h3-5H,1-2H3,(H,11,12)

Application

N-(2-Bromo-4-methylphenyl)acetamide serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of non-steroidal anti-inflammatory drug (NSAID) analogs. Researchers utilize this brominated acetamide in cross-coupling reactions to create novel biaryl structures for drug discovery programs. The compound’s reactive bromine moiety makes it valuable for constructing complex molecules through transition metal-catalyzed reactions in medicinal chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)

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