Description

(4-Bromo-3,5-dimethoxyphenyl)methanol (CAS No. 61367-62-2) is a high-purity aromatic alcohol derivative with the molecular formula C₉H₁₁BrO₃. This compound features a bromo-substituted dimethoxyphenyl ring attached to a hydroxymethyl functional group, making it a versatile intermediate in organic synthesis and pharmaceutical research. Its well-defined structure (IUPAC name: (4-bromo-3,5-dimethoxyphenyl)methanol) ensures consistent reactivity in nucleophilic substitutions and cross-coupling reactions. Supplied as a white to off-white crystalline powder, it is rigorously tested for purity (typically ≥95% by HPLC) and stability under recommended storage conditions (2-8°C in inert atmosphere). Ideal for use in Suzuki-Miyaura couplings, etherifications, and as a precursor for bioactive molecule development.

Properties

• CAS Number: 61367-62-2
• Complexity: 140
• IUPAC Name: (4-bromo-3,5-dimethoxy-phenyl)methanol
• InChI: InChI=1S/C9H11BrO3/c1-12-7-3-6(5-11)4-8(13-2)9(7)10/h3-4,11H,5H2,1-2H3
• InChI Key: TYICCDYGCBAFCB-UHFFFAOYSA-N
• Exact Mass: 245.98916
• Molecular Formula: C9H11BrO3
• Molecular Weight: 247.09
• SMILES: COC1=CC(=CC(=C1Br)OC)CO
• Topological: 38.7
• Monoisotopic Mass: 245.98916
• Synonyms: (4-bromo-3,5-dimethoxyphenyl)methanol, 820-817-3, 4-Bromo-3,5-dimethoxybenzyl alcohol, 61367-62-2, 4-Bromo-3,5-dimethoxybenzylalcohol, Benzenemethanol, 4-bromo-3,5-dimethoxy-, MFCD06658150, 4-Bromo-3,5-dimethoxy-phenyl)-methanol, (4-bromo-3,5-dimethoxyphenyl)methan-1-ol, SCHEMBL918659, DTXSID40456981, TYICCDYGCBAFCB-UHFFFAOYSA-N, SBB063105, 4-Bromo-3,5-dimethoxybenzenemethanol, AKOS015888144, FB70812, (4-bromo-3,5-dimethoxy-phenyl)-methanol, AS-15605, SY109987, DB-005335, CS-0150624, 4-Bromo-3 pound not5-dimethoxybenzyl alcohol, EN300-1707449

Application

This compound serves as a key building block in medicinal chemistry for the synthesis of brominated aromatic scaffolds. Researchers utilize it in palladium-catalyzed cross-coupling reactions to create complex biaryl structures. The dimethoxy and bromo substituents make it particularly valuable in developing CNS-active compounds and kinase inhibitors. It’s also employed in material science for constructing liquid crystal monomers and photoactive polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.