Description

2-Chloroquinoline (CAS 612-62-4) is a high-purity heterocyclic organic compound with the molecular formula C₉H₆ClN. This chlorinated quinoline derivative is a versatile building block in pharmaceutical, agrochemical, and materials science research. As a pale yellow to white crystalline solid, it offers excellent solubility in common organic solvents like ethanol, methanol, and dichloromethane. Our product is rigorously tested to meet the highest purity standards (>98% by HPLC), making it ideal for sensitive synthetic applications. Proper storage at 2-8°C in a tightly sealed container ensures long-term stability. This compound is particularly valuable for nucleophilic substitution reactions due to the reactive 2-position chlorine atom. Available in quantities from grams to kilograms, we provide comprehensive analytical data including ¹H NMR, ¹³C NMR, and mass spectrometry reports with each shipment.

Properties

• CAS Number: 612-62-4
• Complexity: 138
• IUPAC Name: 2-chloroquinoline
• InChI: InChI=1S/C9H6ClN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
• InChI Key: OFUFXTHGZWIDDB-UHFFFAOYSA-N
• Exact Mass: 163.0188769
• Molecular Formula: C9H6ClN
• Molecular Weight: 163.60
• SMILES: C1=CC=C2C(=C1)C=CC(=N2)Cl
• Topological: 12.9
• Monoisotopic Mass: 163.0188769
• Physical Description: Off-white solid; mp = 34-37 deg C;
• Vapor Pressure: 0.00508 [mmHg]
• Synonyms: 2-Chloroquinoline, 612-62-4, QUINOLINE, 2-CHLORO-, NSC 6163, CCRIS 3977, UX7RIN8GEW, EINECS 210-317-8, BRN 0112561, AI3-08909, NSC-6163, CHLOROQUINOLINE, 2-, DTXSID8060612, 5-20-07-00312 (Beilstein Handbook Reference), Quinoline, 2chloro, DTXCID2042985, 210-317-8, 2-chloro-quinoline, Chloroquinoline, MFCD00006741, NSC6163, Quinoline, chloro-, UNII-UX7RIN8GEW, chioroquinoline, 2-Chloroquinoline, 99%, SCHEMBL7252, SCHEMBL466391, SCHEMBL865202, SCHEMBL4462081, SCHEMBL4851470, SCHEMBL6232953, CHEMBL2042580, SCHEMBL14127304, SCHEMBL20265138, OFUFXTHGZWIDDB-UHFFFAOYSA-, ALBB-025860, STR07222, BBL100153, SBB056975, STL511939, AKOS000120670, AB00798, AC-2439, CS-W007458, FC15072, SY001152, DB-012685, EU-0033663, NS00034626, ST45029025, EN300-20994, AH-034/32825008, SR-01000390732, doi:10.14272/OFUFXTHGZWIDDB-UHFFFAOYSA-N.1, SR-01000390732-1, Q27291324, F0451-0421, Z104485978, InChI=1/C9H6ClN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H

Application

2-Chloroquinoline serves as a key intermediate in the synthesis of various biologically active compounds, particularly in antimalarial and antibacterial drug development. Researchers utilize this compound to create quinoline-based ligands for catalytic systems and metal-organic frameworks. In material science, it finds application as a precursor for organic semiconductors and luminescent materials. The reactive chlorine position enables facile functionalization for structure-activity relationship studies in medicinal chemistry programs.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.