Description

2-Nitrothiophene (CAS 609-40-5) is a high-purity heterocyclic organic compound with the molecular formula C₄H₃NO₂S, widely utilized in pharmaceutical, agrochemical, and materials science research. This yellow crystalline solid exhibits excellent reactivity due to the presence of both a nitro group and a thiophene ring, making it a versatile intermediate for synthesizing complex molecules. With a molecular weight of 129.14 g/mol and a melting point of 43-45°C, it is optimized for controlled reactions. Our product is rigorously tested via GC/HPLC to ensure ≥98% purity, meeting the stringent requirements of industrial and academic laboratories. Packaged under inert gas to prevent degradation, it is available in scalable quantities from grams to kilograms.

Properties

• CAS Number: 609-40-5
• Complexity: 101
• IUPAC Name: 2-nitrothiophene
• InChI: InChI=1S/C4H3NO2S/c6-5(7)4-2-1-3-8-4/h1-3H
• InChI Key: JIZRGGUCOQKGQD-UHFFFAOYSA-N
• Exact Mass: 128.98844951
• Molecular Formula: C4H3NO2S
• Molecular Weight: 129.14
• SMILES: C1=CSC(=C1)[N+](=O)[O-]
• Topological: 74.1
• Monoisotopic Mass: 128.98844951
• Synonyms: 2-NITROTHIOPHENE, 609-40-5, Thiophene, 2-nitro-, NSC 5371, EINECS 210-190-9, AI3-16618, DTXSID9060570, DTXCID0042903, 210-190-9, 2-nitro-thiophene, MFCD00005425, 2-Nitrothiophene (Technical Grade), alpha-Nitrothiophene, NSC-5371, nitrothiophene, o-Nitrothiophene, 2-Nitrothiofene, NSC5371, 2-Nitrothiophene, tech., WLN: T5SJ BNW, WW8M82QUP5, BIDD:GT0164, SCHEMBL136001, SCHEMBL233024, SCHEMBL446319, SCHEMBL451638, JIZRGGUCOQKGQD-UHFFFAOYSA-, SBB040890, STL282559, AKOS000268995, AC-4912, CS-W016550, FN15217, GS-6133, 2-Nitrothiophene, 85%, technical grade, SY057576, DB-053752, N0407, NS00034502, ST50214486, EN300-17306, F13472, Q27452741, InChI=1/C4H3NO2S/c6-5(7)4-2-1-3-8-4/h1-3H

Application

2-Nitrothiophene serves as a key precursor in the synthesis of pharmaceuticals, particularly for antimicrobial and antitumor agents. Its electron-deficient thiophene ring facilitates electrophilic substitution reactions, enabling the development of novel heterocyclic compounds. Researchers also employ it in organic electronics due to its conjugated system, which enhances charge transport in semiconducting materials.

Safety and Hazards

GHS Hazard Statements

• H302 (37.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (37.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (37.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H341 (87.5%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

Precautionary Statements

• P203, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P362+P364, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (37.5%)
• Acute Tox. 4 (37.5%)
• Acute Tox. 4 (37.5%)
• Muta. 2 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.