Description

Lithium Citrate Tetrahydrate (CAS No. 6080-58-6) is a high-purity, crystalline lithium salt of citric acid, supplied as the tetrahydrate form with the molecular formula C₆H₁₃Li₃O₁₁. This pharmaceutical-grade compound is widely utilized in research and clinical applications due to its stable hydration state and excellent solubility in aqueous solutions. It serves as a critical reagent in biochemistry, neuropharmacology, and electrolyte balance studies, particularly in investigations involving lithium’s therapeutic effects. Each batch undergoes rigorous quality control, including HPLC and ICP-MS analysis, to ensure ≥99% purity and compliance with USP/Ph. Eur. standards. The product is packaged under inert conditions to prevent moisture absorption and degradation, with optional custom formulations available for specialized research needs.

Properties

• CAS Number: 6080-58-6
• Complexity: 211
• IUPAC Name: trilithium;citrate;tetrahydrate
• InChI: InChI=1S/C6H8O7.3Li.4H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;4*1H2/q;3*+1;;;;/p-3
• InChI Key: HXGWMCJZLNWEBC-UHFFFAOYSA-K
• Exact Mass: 282.0937965
• Molecular Formula: C6H13Li3O11
• Molecular Weight: 282.1
• SMILES: [Li+].[Li+].[Li+].C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.O.O.O.O
• Topological: 145
• Monoisotopic Mass: 282.0937965
• Synonyms: 6080-58-6, Trilithium citrate tetrahydrate, LITHIUM CITRATE TETRAHYDRATE, Lithium citrate tribasic tetrahydrate, Lithonate s, Lithium citrate [USP], trilithium;2-hydroxypropane-1,2,3-tricarboxylate;tetrahydrate, 5Z6E9K79YV, CHEBI:64754, Litarex, Citric acid (trilithium salt tetrahydrate), Lithium citrate (USP), Lithium citrate tribasic tetrahydrate;Trilithium citrate tetrahydrate, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-trilithium salt tetrahydrate, 1,2,3-Propanetricarboxylicacid, 2-hydroxy-, lithium salt, hydrate (1:3:4), MFCD00150030, UNII-5Z6E9K79YV, Citric acid, trilithium salt tetrahydrate, tri-lithium citrate tetrahydrate, Citric Acid Trilithium Tetrahydrate, SCHEMBL372316, LITHIUM CITRATE [VANDF], CHEMBL2103738, LITHIUM CITRATE [WHO-DD], LITHIUM CITRATE [ORANGE BOOK], AKOS025310745, LITHIUM (AS CITRATE) [VANDF], NSC 758700, LITHIUM CITRATE TETRAHYDRATE [MI], AS-73044, DA-78619, D04749, F85256, Q27133402, lithium 2-hydroxypropane-1,2,3-tricarboxylate tetrahydrate, lithium 2-hydroxypropane-1,2,3-tricarboxylate–water (1/4), trilithium(1+) 2-hydroxypropane-1,2,3-tricarboxylate tetrahydrate

Lithium citrate tetrahydrate is primarily employed as a mood-stabilizing agent in psychiatric research, particularly for studying bipolar disorder mechanisms. It serves as a key electrolyte in in vitro neuronal studies investigating lithium’s neuroprotective effects. The compound is also utilized in metabolic pathway analysis due to citrate’s central role in the Krebs cycle, with applications extending to isotope-labeling experiments (e.g., ⁷Li NMR studies).

Safety and Hazards

GHS Hazard Statements

• H302 (41.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (58.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (58.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (58.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (41.5%)
• Skin Irrit. 2 (58.5%)
• Eye Irrit. 2 (58.5%)
• STOT SE 3 (58.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.