Description

5-Amino-2-fluorobenzoic acid (CAS: 56741-33-4) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₆FNO₂. This versatile intermediate is widely used in pharmaceutical synthesis, agrochemical research, and material science applications. The compound features both an amino (-NH₂) and carboxylic acid (-COOH) functional group on a fluorinated benzene ring, making it particularly valuable for constructing complex molecules through targeted derivatization.

Our premium grade material is supplied as a white to off-white crystalline powder with ≥98% purity (HPLC). Rigorous QC testing ensures low levels of heavy metals (<10 ppm) and residual solvents. The product is packaged under inert gas in amber glass vials or bulk quantities with desiccant to maintain stability.

Key applications include: building block for kinase inhibitors, precursor for PET radiotracers, and intermediate in liquid crystal synthesis. SDS and analytical certificates are available upon request. Store at 2-8°C in a dry environment.

Properties

• CAS Number: 56741-33-4
• Complexity: 163
• IUPAC Name: 5-amino-2-fluoro-benzoic acid
• InChI: InChI=1S/C7H6FNO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,9H2,(H,10,11)
• InChI Key: WYGAIOJWQDRBRJ-UHFFFAOYSA-N
• Exact Mass: 155.03825660
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.13
• SMILES: C1=CC(=C(C=C1N)C(=O)O)F
• Topological: 63.3
• Monoisotopic Mass: 155.03825660
• Synonyms: 5-Amino-2-fluorobenzoic acid, 56741-33-4, DTXSID10371016, DTXCID80322050, 629-949-4, 3-amino-6-fluorobenzoic acid, MFCD00077449, 5-Amino-2-fluorobenzioc acid, 5-Amino-2-fluorobenzoicacid, 5-amino-2-fluoro-benzoic Acid, Benzoic acid, 5-amino-2-fluoro-, 2-fluoro-5-aminobenzoic acid, SCHEMBL416879, 3-amino-6-fluoro-benzoic acid, WYGAIOJWQDRBRJ-UHFFFAOYSA-N, BBL028158, CK2230, SBB028316, STL353603, AKOS001419368, AC-3885, CS-W016257, FA70089, PS-8865, SB76046, SY030633, 5-Amino-2-fluorobenzoic acid, AldrichCPR, DB-024137, ST51041467, EN300-29773, Z235362843

5-Amino-2-fluorobenzoic acid serves as a critical intermediate in medicinal chemistry for developing tyrosine kinase inhibitors and other targeted therapeutics. Researchers utilize its bifunctional structure to create novel benzamide derivatives with enhanced pharmacokinetic properties. The fluorine atom enables strategic modifications for improved metabolic stability in drug candidates. This compound also finds use in synthesizing advanced materials with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (88.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (88.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (11.1%)
• Skin Irrit. 2 (88.9%)
• Eye Irrit. 2A (88.9%)
• STOT SE 3 (88.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.