Description

Magnesium, chloro(2-methylpropyl)- (CAS No. 5674-02-2), also known as Isobutylmagnesium chloride, is a highly reactive Grignard reagent widely utilized in organic synthesis and pharmaceutical research. With the molecular formula C₄H₉ClMg, this compound is typically supplied as a solution in tetrahydrofuran (THF) at concentrations such as 2M for precise laboratory applications. Its robust nucleophilic properties make it indispensable for carbon-carbon bond formation, alkylation reactions, and the synthesis of complex organic molecules. Ideal for researchers and scientists, this reagent is rigorously tested for purity and stability, ensuring consistent performance in demanding experimental conditions. Store under inert gas (e.g., argon or nitrogen) to maintain reactivity and prevent degradation.

Properties

• CAS Number: 5674-02-2
• Complexity: 15
• IUPAC Name: magnesium;2-methanidylpropane;chloride
• InChI: InChI=1S/C4H9.ClH.Mg/c1-4(2)3;;/h4H,1H2,2-3H3;1H;/q-1;;+2/p-1
• InChI Key: YSMZEMQBSONIMJ-UHFFFAOYSA-M
• Exact Mass: 116.0243197
• Molecular Formula: C4H9ClMg
• Molecular Weight: 116.87
• SMILES: CC(C)[CH2-].[Mg+2].[Cl-]
• Monoisotopic Mass: 116.0243197
• Synonyms: 5674-02-2, Magnesium, chloro(2-methylpropyl)-, DTXSID60884181, Chloro(2-methylpropyl)magnesium, DTXCID001023641, 627-131-1, ISOBUTYLMAGNESIUM CHLORIDE, 2-Methylpropylmagnesium chloride, ISO-BUTYLMAGNESIUM CHLORIDE, magnesium;2-methanidylpropane;chloride, iBuMgCl, i-BuMgCl, i-butylmagnesium chloride, isobutyl magnesium chloride, SCHEMBL11018, 674-02-2, Chloro-(2-methylpropyl)magnesium, YUPZOKFCNKSJTR-UHFFFAOYSA-M, MFCD00000471, AKOS015915840, Isobutylmagnesium chloride, 2M in THF

Isobutylmagnesium chloride (i-BuMgCl) is primarily used in Grignard reactions to introduce the isobutyl group into organic substrates. It is particularly valuable in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The reagent also serves as a precursor for preparing organometallic catalysts and modifying polymer chains. Due to its high reactivity, it requires careful handling under anhydrous conditions.

Safety and Hazards

GHS Hazard Statements

• H225 (16.4%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H250 (60.8%): Catches fire spontaneously if exposed to air [Danger Pyrophoric liquids]
• H260 (100%): In contact with water releases flammable gases which may ignite spontaneously [Danger Substances and mixtures which in contact with water, emit flammable gases]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (62%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P210, P222, P223, P231, P231+P232, P233, P240, P241, P242, P243, P260, P264, P264+P265, P280, P301+P330+P331, P302+P335+P334, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P363, P370+P378, P402+P404, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (16.4%)
• Pyr. Liq. 1 (60.8%)
• Water-react. 1 (100%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (62%)

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