Description

2,4-Difluorobenzyl alcohol (CAS No. 56456-47-4) is a high-purity fluorinated aromatic alcohol with the molecular formula C₇H₆F₂O. This compound, also known by its IUPAC name (2,4-difluorophenyl)methanol, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring two fluorine atoms at the 2- and 4-positions of the benzyl ring, enhances its reactivity and utility in cross-coupling reactions, nucleophilic substitutions, and as a precursor for advanced intermediates.

Our product is rigorously tested to ensure ≥98% purity (GC), with stringent controls for moisture and impurities. It is supplied as a clear, colorless to pale-yellow liquid, packaged under inert gas to maintain stability. Ideal for researchers in medicinal chemistry, agrochemical development, and material science, this compound is available in quantities ranging from grams to kilograms, with custom synthesis options available.

Properties

• CAS Number: 56456-47-4
• Complexity: 108
• IUPAC Name: (2,4-difluorophenyl)methanol
• InChI: InChI=1S/C7H6F2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2
• InChI Key: NIJZBWHOHNWJBX-UHFFFAOYSA-N
• Exact Mass: 144.03867113
• Molecular Formula: C7H6F2O
• Molecular Weight: 144.12
• SMILES: C1=CC(=C(C=C1F)F)CO
• Topological: 20.2
• Monoisotopic Mass: 144.03867113
• Synonyms: 2,4-Difluorobenzyl alcohol, 56456-47-4, (2,4-Difluorophenyl)methanol, Benzenemethanol, 2,4-difluoro-, EINECS 260-191-3, 2,4-Difluorobenzenemethanol, 2,4-DIFLUOROBENZYL ALCOHOL 2,4-DIFLUORO-1-(HYDROXYMETHYL)BENZENE, NIJZBWHOHNWJBX-UHFFFAOYSA-, DTXSID70205005, DTXCID30127496, 260-191-3, inchi=1/c7h6f2o/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10h,4h2, SVX5XQB2MB, MFCD00009983, 2,4-Difluorobenzylalcohol, (2,4-difluorophenyl)methan-1-ol, 24B, UNII-SVX5XQB2MB, 2,4-diflouro benzyl alcohol, SCHEMBL93024, 2, 4-Difluorobenzyl alcohol, SCHEMBL132365, SCHEMBL518007, SCHEMBL596981, 2,4-Difluorobenzaldehyde (M5), (2,4-Difluorophenyl)methanol #, SBB064044, AKOS000249420, AC-9731, DB04448, PS-8987, PD006207, SY016333, DB-019935, CS-0071857, D1838, NS00054203, ST50823886, A22574, EN300-1263452, Q27095232, F8882-0289, (2,4-Difluoro-phenyl)-methanol;Benzenemethanol, 2,4-difluoro-

Application

2,4-Difluorobenzyl alcohol is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of antifungal and antiviral agents. Its fluorinated aromatic structure makes it valuable for modifying drug lipophilicity and bioavailability. Researchers also employ it in the preparation of liquid crystals and specialty polymers, where its fluorine substituents enhance thermal and chemical resistance. Additionally, it serves as a precursor for ligands in catalytic systems and as a building block in agrochemical formulations.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.