Description

Glycidol (CAS 556-52-5) is a highly versatile and reactive epoxide compound with the molecular formula C₃H₆O₂. Also known by its IUPAC name oxiran-2-ylmethanol, this colorless liquid is widely utilized in organic synthesis, pharmaceuticals, and polymer chemistry. Glycidol features both an epoxide ring and a hydroxyl group, enabling its use as a bifunctional building block for crosslinking, alkylation, and polymerization reactions. With a molecular weight of 74.08 g/mol and a boiling point of 166°C, it offers excellent solubility in water and most organic solvents. Ideal for researchers and industrial scientists, our high-purity Glycidol (>98%) is rigorously tested for consistency, ensuring optimal performance in advanced chemical applications.

Properties

• CAS Number: 556-52-5
• Complexity: 35.9
• IUPAC Name: oxiran-2-ylmethanol
• InChI: InChI=1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2
• InChI Key: CTKINSOISVBQLD-UHFFFAOYSA-N
• LogP: log Kow = -0.95
• Exact Mass: 74.036779430
• Molecular Formula: C3H6O2
• Molecular Weight: 74.08
• SMILES: C1C(O1)CO
• Topological: 32.8
• Monoisotopic Mass: 74.036779430
• Physical Description: Glycidol is an odorless clear colorless liquid.
• Color/Form: Colorless, slightly viscous liquid
• Boiling Point: 333 °F at 760 mmHg
• Melting Point: -49 °F
• Flash Point: 162 °F
• Solubility: greater than or equal to 100 mg/mL at 64 °F
• Density: 1.1143 at 77 °F – Denser than water; will sink
• Vapor Density: 2.15 – Heavier than air; will sink
• Vapor Pressure: 0.9 mmHg at 77 °F ; 2.5 mmHg at 151 °F
• Autoignition Temperature: 415 °C
• Refractive Index: Index of refraction = 1.4287 at 20 °C/D
• Synonyms: GLYCIDOL, 556-52-5, oxiran-2-ylmethanol, Oxiranemethanol, 1-Propanol, 2,3-epoxy-, 2,3-Epoxy-1-propanol, Glycide, Oxiranylmethanol, Epihydrin alcohol, 3-Hydroxypropylene oxide, 2-(Hydroxymethyl)oxirane, 2,3-Epoxypropanol, Glycidyl alcohol, 2-Oxiranemethanol, Epoxypropyl alcohol, Allyl alcohol oxide, Monoepoxide glycidol, Methanol, oxiranyl-, 2,3-Epoxypropan-1-ol, 3-Hydroxy-1,2-epoxypropane, 1,2-Epoxy-3-hydroxypropane, 1-Hydroxy-2,3-epoxypropane, 2-Hydroxymethyloxiran, Hydroxymethyl ethylene oxide, NCI-C55549, NSC 46096, CCRIS 1052, HSDB 1819, EINECS 209-128-3, S54CF1DV9A, BRN 0383562, DTXSID4020666, CHEBI:30966, AI3-50540, D-L-GLYCIDOL, GLYCIDOL [HSDB], GLYCIDOL [IARC], GLYCIDOL [MI], NSC-46096, R-2,3-epoxy-1-propanol, DTXCID60666, GLYCIDOL [EP IMPURITY], EC 209-128-3, NSC46096, GLYCIDOL (IARC), LEVODROPROPIZINE IMPURITY C [EP IMPURITY], GLYCIDOL (EP IMPURITY), 2-Hydroxymethyl oxiran, LEVODROPROPIZINE IMPURITY C (EP IMPURITY), Oxirane methanol, 2,3Epoxypropanol, Methanol, oxiranyl, 2Hydroxymethyloxiran, 2,3Epoxy1propanol, 3Hydroxypropylene oxide, EPIOL OH, 1Propanol, 2,3epoxy, Oxyranyl Methyl Alcohol, 2(Hydroxymethyl)oxirane, 1,2Epoxy3hydroxypropane, 1Hydroxy2,3epoxypropane, 3Hydroxy1,2epoxypropane, Glycidol (ACGIH:OSHA), 2,3-Epoxy-1-propanol (ACGIH:OSHA), 209-128-3, 404-660-4, (S)-Oxiranemethanol, (+/-)-Glycidol, (RS)-Glycidol, (RS)-3-hydroxy-1,2-epoxypropane, Oxiranemethanol, (R)-, Oxiranemethanol, (S)-, (oxiran-2-yl)methanol, (+/-)-Oxirane-2-methanol, S-Glycidol, C3H6O2, Glycidol (~90%), 5-17-03-00009 (Beilstein Handbook Reference), Glycerolglycide, 2-Oxiranylmethanol #, CAS-556-52-5, 2,3-Epoxypropanol-1, UNII-S54CF1DV9A, Glycerol glycid, glycerol glycide, CCRIS 6389, CCRIS 6390, oxiranyl-methanol, 2-Oxiranylmethanol, Hydroxymethyloxirane, Glycidol; Oxiran-2-ylmethanol; [(2RS)-Oxiran-2-yl]methanol; Levodropropizine EP impurity C; 2,3-epoxypropan-1-ol, Glycidol, 96%, (RS)-Oxiranemethanol, DL-GLYCIDOL, BRN 0079782, BRN 0079783, 1-Propanol,3-epoxy-, (S)-(?)-Glycidol, WLN: T3OTJ B1Q, SCHEMBL9182, SCHEMBL15684, MLS002174255, SCHEMBL2139092, SCHEMBL2183618, SCHEMBL8976771, CHEMBL1530150, SCHEMBL10746016, (+/-)-2-(hydroxymethyl)oxirane, HMS3039K06, HY-Y1010, STR01325, Tox21_201309, Tox21_300301, MFCD00005147, MFCD00074873, STL483075, (+/-)-Glycidol, analytical standard, AKOS009031473, FG23681, PB43085, SB40756, SB44653, NCGC00090738-01, NCGC00090738-02, NCGC00090738-03, NCGC00090738-04, NCGC00253997-01, NCGC00258861-01, SMR001261426, SY013955, SY031944, CS-0016001, NS00006946, EN300-19950, A10767, EC 404-660-4, Glycidol Epoxypropyl alcohol 2,3-Epoxy-1-propanol, Q418265, F0001-1460, Z104476180, Levodropropizine impurity C, European Pharmacopoeia (EP) Reference Standard, (R)-3-Hydroxy-1,2-epoxypropane; (R)-Oxiranemethanol; (R)-(+)-Oxirane-2-methanol, (S)-(-)-Glycidol; (S)-(-)-2,3-Epoxy-1-propanol; (R)-3-Hydroxy-1,2-epoxypropane; [(2R)-Oxiran-2-yl]methanol

Application

Glycidol is a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty polymers. Its reactive epoxide group facilitates ring-opening reactions to produce glycerol derivatives, glycidyl ethers, and other functionalized compounds. In polymer science, it serves as a monomer for producing polyglycidol and modifying resins for coatings, adhesives, and composites. Additionally, Glycidol is employed in the preparation of chiral auxiliaries and as a crosslinking agent in epoxy systems.

Safety and Hazards

GHS Hazard Statements

• H227: Combustible liquid [Warning Flammable liquids]
• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]
• H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331: Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]
• H350: May cause cancer [Danger Carcinogenicity]
• H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
• H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]
• H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P203, P210, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P317, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Self-react. C (100%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (50%)
• Acute Tox. 2 (50%)
• Acute Tox. 3 (50%)
• STOT SE 3 (50%)
• Muta. 2 (100%)
• Carc. 1B (100%)
• Repr. 1B (50%)
• Repr. 1B (50%)

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