Description

Phenyl Vinyl Sulfone (CAS No. 5535-48-8) is a high-purity organic compound with the molecular formula C₈H₈O₂S and IUPAC name ethenylsulfonylbenzene. This versatile sulfone derivative is characterized by its reactive vinyl sulfone group, making it a valuable intermediate in organic synthesis, polymer chemistry, and pharmaceutical research. The compound appears as a white to off-white crystalline solid with excellent stability under standard conditions. It is soluble in common organic solvents such as acetone, DMSO, and dichloromethane, but exhibits limited solubility in water. Phenyl Vinyl Sulfone is supplied with comprehensive analytical documentation including ¹H NMR, ¹³C NMR, and HPLC purity data (typically ≥98%). Proper storage recommendations include protection from light at 2-8°C in a tightly sealed container. This product is ideal for researchers working on Michael addition reactions, click chemistry, or the development of novel polymeric materials.

Properties

• CAS Number: 5535-48-8
• Complexity: 217
• IUPAC Name: vinylsulfonylbenzene
• InChI: InChI=1S/C8H8O2S/c1-2-11(9,10)8-6-4-3-5-7-8/h2-7H,1H2
• InChI Key: UJTPZISIAWDGFF-UHFFFAOYSA-N
• Exact Mass: 168.02450067
• Molecular Formula: C8H8O2S
• Molecular Weight: 168.21
• SMILES: C=CS(=O)(=O)C1=CC=CC=C1
• Topological: 42.5
• Monoisotopic Mass: 168.02450067
• Synonyms: Phenyl vinyl sulfone, 5535-48-8, (ethenylsulfonyl)benzene, Benzene, (ethenylsulfonyl)-, Sulfone, phenyl vinyl, Vinylsulfonylbenzene, Phenyl vinyl sulphone, Ethenesulfonyl-benzene, EINECS 226-890-2, NSC-35394, ETHENYL PHENYL SULFONE, 31973457VY, DTXSID50203903, URI-744, PHENYL VINYL SULFONE [MI], NSC 35394, PVS cpd, DTXCID40126394, (Vinylsulfonyl)benzene, ethenylsulfonylbenzene, (ethenesulfonyl)benzene, phenyl vinylsulfone, MFCD00007554, CHEMBL165058, URI 744, Phenylvinylsulfone, phenylvinylsulphone, (Ethenylsulfonyl)benzene; Ethenyl Phenyl Sulfone; NSC 35394; URI 744; Vinylsulfonylbenzene, UNII-31973457VY, ethenesulfonylbenzene, (Vinylsulfonyl)benzene #, Phenyl vinyl sulfone, 99%, SCHEMBL45672, SCHEMBL1374138, SCHEMBL4698110, SCHEMBL5524215, SCHEMBL8084235, SCHEMBL9540908, SCHEMBL13341764, CS-M1815, NSC35394, BDBM50125084, STK695234, AKOS005146278, NCGC00665623-01, AS-17307, SY019515, ST4147555, NS00033299, P0982, EN300-65394, O10233, Q27256031, Z1020737978

Application

Phenyl Vinyl Sulfone serves as a key building block in organic synthesis, particularly in Michael addition reactions due to its electron-deficient vinyl group. In polymer science, it functions as a cross-linking agent or comonomer for creating specialty polymers with enhanced thermal and chemical resistance. The compound finds additional utility in pharmaceutical research as a precursor for sulfone-containing drug candidates and in material science for surface modification applications.

Safety and Hazards

GHS Hazard Statements

• H302 (83.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (91.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (81.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (16.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (83.3%)
• Skin Irrit. 2 (97.9%)
• Skin Sens. 1 (91.7%)
• Eye Dam. 1 (81.2%)
• Eye Irrit. 2A (16.7%)
• STOT SE 3 (95.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.