Description

5-Bromo-2-chloropyridine (CAS No. 53939-30-3) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃BrClN. This heterocyclic compound is a versatile building block in pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring both bromine and chlorine substituents on the pyridine ring, enables selective functionalization via cross-coupling reactions (e.g., Suzuki, Stille) or nucleophilic substitutions. Offered as a white to off-white crystalline solid with ≥98% purity (HPLC), it is rigorously tested for trace metals, residual solvents, and moisture content. Packaged under inert gas in amber glass vials to ensure stability, this product is ideal for synthesizing active pharmaceutical intermediates (APIs), ligands, and functionalized materials. MSDS and analytical certificates (CoA) are available upon request.

Properties

• CAS Number: 53939-30-3
• Complexity: 78.8
• IUPAC Name: 5-bromo-2-chloro-pyridine
• InChI: InChI=1S/C5H3BrClN/c6-4-1-2-5(7)8-3-4/h1-3H
• InChI Key: PEAOEIWYQVXZMB-UHFFFAOYSA-N
• Exact Mass: 190.91374
• Molecular Formula: C5H3BrClN
• Molecular Weight: 192.44
• SMILES: C1=CC(=NC=C1Br)Cl
• Topological: 12.9
• Monoisotopic Mass: 190.91374
• Synonyms: 5-Bromo-2-chloropyridine, 53939-30-3, PEAOEIWYQVXZMB-UHFFFAOYSA-, DTXSID80370293, DTXCID60321329, 700-053-6, inchi=1/c5h3brcln/c6-4-1-2-5(7)8-3-4/h1-3h, peaoeiwyqvxzmb-uhfffaoysa-n, 2-Chloro-5-bromopyridine, MFCD01318951, 5-bromo-2-chloro-pyridine, 2-chloro-5-bromo-pyridine, PYRIDINE, 5-BROMO-2-CHLORO-, 2-chloro-5-bromo pyridine, SCHEMBL182768, SCHEMBL7969354, SCHEMBL9480525, SCHEMBL19209881, 5-Bromo-2-chloropyridine, 95%, BCP23163, BBL012798, SBB013973, STK688509, AKOS000118107, AB08767, AC-3111, CS-W002767, FB06182, FG-0471, HY-W002767, SY003852, DB-012178, ST4128286, B2329, EN300-27448, A847802, F0001-1404, Z239604476

Application

5-Bromo-2-chloropyridine serves as a key intermediate in the synthesis of biologically active compounds, including kinase inhibitors and antiviral agents. Its halogenated structure facilitates palladium-catalyzed cross-coupling reactions to construct complex heterocycles for drug discovery. Researchers also utilize it to develop ligands for catalysis and functionalized polymers in materials science. In agrochemistry, it is employed to create novel pesticides and herbicides.

Safety and Hazards

GHS Hazard Statements

• H315 (98.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (98.7%)
• Eye Irrit. 2 (98.7%)
• STOT SE 3 (97.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.