Description

2-Chloroacetophenone (CAS No. 532-27-4), also known as Phenacyl chloride, is an organic compound with the molecular formula C₈H₇ClO. This aromatic ketone features a chloro-substituted acetyl group attached to a phenyl ring, making it a versatile intermediate in organic synthesis. With a purity grade suitable for laboratory and industrial applications, our 2-Chloroacetophenone is rigorously tested to ensure consistency and reliability for researchers and scientists. It is commonly employed in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Available in various quantities, this compound is packaged under controlled conditions to maintain stability and shelf life. Handle with care, as it may cause irritation to skin, eyes, and respiratory system.

Properties

• CAS Number: 532-27-4
• Complexity: 116
• IUPAC Name: 2-chloro-1-phenyl-ethanone
• InChI: InChI=1S/C8H7ClO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2
• InChI Key: IMACFCSSMIZSPP-UHFFFAOYSA-N
• LogP: 2.08
• Exact Mass: 154.0185425
• Molecular Formula: C8H7ClO
• Molecular Weight: 154.59
• SMILES: C1=CC=C(C=C1)C(=O)CCl
• Topological: 17.1
• Monoisotopic Mass: 154.0185425
• Physical Description: 2-chloroacetophenone appears as a riot control agent and chemical warfare tear gas agent. A white crystalline solid. Denser than water and insoluble in water. Hence sinks in water. A lachrymator: vapors are very irritating to the eyes. Has a floral odor.
• Color/Form: Crystals from dilute alcohol, carbon tetrachloride, or light petroleum
• Odor: IN VERY LOW CONCN IN AIR IT HAS AN ODOR RESEMBLING APPLE BLOSSOMS
• Boiling Point: 441 to 442 °F at 760 mmHg
• Melting Point: 133.7 °F
• Flash Point: 244 °F
• Solubility: less than 1 mg/mL at 66 °F
• Density: 1.32 at 59 °F – Denser than water; will sink
• Vapor Density: 5.2 – Heavier than air; will sink
• Vapor Pressure: 0.0054 mmHg at 68 °F
• Ionization Potential: 9.44 eV
• Odor Threshold: Odor Threshold Low: 0.01 [ppm]
• Synonyms: 2-CHLOROACETOPHENONE, 532-27-4, Phenacyl chloride, 2-Chloro-1-phenylethanone, omega-Chloroacetophenone, CHLOROACETOPHENONE, alpha-Chloroacetophenone, Tear Gas, Mace (lacrimator), Chloromethyl phenyl ketone, Ethanone, 2-chloro-1-phenyl-, Phenacylchloride, Chemical mace, Mace, 1-Chloroacetophenone, Acetophenone, 2-chloro-, CN (lacrimator), Chloracetophenone, Phenyl chloromethyl ketone, NCI-C55107, 2-Chloro-1-phenylethan-1-one, .alpha.-Chloroacetophenone, 2-Chloroacetophenone (CN), 2-Chloro-1-phenyl-ethanone, MFCD00000933, NSC 41666, .alpha.-Phenacyl chloride, .omega.-Chloroacetophenone, CHEMBL105712, DTXSID9020293, 88B5039IQG, NSC-41666, a-Chloroacetophenone, DTXCID90293, Phenylchloromethylketone, Caswell No. 179C, CAS-532-27-4, ?-Chloroacetophenone, CCRIS 2370, HSDB 972, Chloroacetophenone, 2-, EINECS 208-531-1, EPA Pesticide Chemical Code 018001, BRN 0507950, Benzeneacetaldehyde, a-chloro-, UNII-88B5039IQG, AI3-52322, Nutmeg fat, Nutmeg oleoresin, minyak bunga pala, minyak phuli pala, 2-chloroacetophenon, Chloroacetyl benzene, mace oil east indian, Benzoylmethyl chloride, 2-chloro acetophenone, 2-chloro-acetophenone, I+/–chloroacetophenone, mace indonesia oil fg 5, UNII-9KKX6I0U7Z, WLN: G1VR, 2-Chloroacetophenone, 98%, 9KKX6I0U7Z, SCHEMBL55444, 4-07-00-00641 (Beilstein Handbook Reference), Chloroacetophenone (CN), solid [UN1697] [Poison], (2-Chloro-1-oxoethyl)benzene, FEMA No. 2652, FEMA No. 2653, FEMA No. 2654, 1-Phenyl-2-chloro-1-ethanone, BDBM7873, Chloroacetophenone (CN), solid, GTPL6285, PHENYL CHLOROMETHYLKETONE, SCHEMBL1679834, SCHEMBL7516064, SCHEMBL7516073, Chloroacetophenone (CN), liquid, HSDB 1950, Mace (Myristica fragrans Houtt.), CHLOROACETOPHENONE [MART.], NCI-C56484, NSC41666, STR01480, Halomethyl Phenyl Ketone deriv. 21, Tox21_202075, Tox21_300045, NM-003, AKOS000200777, OMEGA-CHLOROACETOPHENONE [HSDB], UN 1697, .OMEGA.-CHLOROACETOPHENONE [MI], NCGC00091207-01, NCGC00091207-02, NCGC00091207-03, NCGC00091207-04, NCGC00091207-05, NCGC00091207-06, NCGC00254035-01, NCGC00259624-01, DB-013352, NS00020661, 2-Chloroacetophenone, purum, >=98.0% (GC), Q284209, Chloroacetophenone (CN), liquid [UN1697] [Poison], Z57834468

Application

2-Chloroacetophenone is widely used as a key intermediate in the synthesis of pharmaceuticals, including anti-inflammatory and analgesic agents. It serves as a precursor in the production of agrochemicals such as herbicides and insecticides. Additionally, this compound is utilized in organic chemistry research for the preparation of heterocyclic compounds and other fine chemicals. Its reactivity makes it valuable in Friedel-Crafts acylation reactions and other electrophilic aromatic substitutions.

Safety and Hazards

GHS Hazard Statements

• H301: Toxic if swallowed [Danger Acute toxicity, oral]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]
• H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
• H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]
• H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P308+P316, P317, P319, P321, P330, P332+P317, P333+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 2 (100%)
• Acute Tox. 3 (74.1%)
• Skin Irrit. 2 (94.4%)
• Skin Sens. 1 (18.5%)
• Eye Dam. 1 (92.6%)
• Acute Tox. 1 (13%)
• Acute Tox. 3 (75.9%)
• Resp. Sens. 1 (85.2%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.