Description

Malonyl-CoA (CAS: 524-14-1) is a critical metabolic intermediate in fatty acid biosynthesis and other essential biochemical pathways. This high-purity compound, with the molecular formula C₂₄H₃₈N₇O₁₉P₃S, is a coenzyme A derivative that plays a pivotal role in the elongation of fatty acid chains via the fatty acid synthase (FAS) complex. It serves as a two-carbon donor in the malonyl-CoA pathway, making it indispensable for lipid metabolism research.

Our premium-grade Malonyl-CoA is rigorously tested for purity and stability, ensuring optimal performance in enzymatic assays, metabolic studies, and synthetic biology applications. It is supplied as a lyophilized powder or in solution, with strict quality control to meet the demands of academic, pharmaceutical, and industrial researchers.

Key Features:

• High purity (≥95% by HPLC)
• Stable under recommended storage conditions (-20°C)
• Compatible with enzymatic and analytical applications
• Available in customizable quantities for lab-scale to bulk requirements

Ideal for studying fatty acid metabolism, polyketide synthesis, and mitochondrial function, our Malonyl-CoA is a trusted reagent for scientists advancing metabolic engineering and drug discovery.

Properties

• CAS Number: 524-14-1
• Complexity: 1490
• IUPAC Name: 3-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxo-propanoic acid
• InChI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/t12-,17-,18-,19+,23-/m1/s1
• InChI Key: LTYOQGRJFJAKNA-DVVLENMVSA-N
• Exact Mass: 853.11560417
• Molecular Formula: C24H38N7O19P3S
• Molecular Weight: 853.6
• SMILES: CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)CC(=O)O)O
• Topological: 426
• Monoisotopic Mass: 853.11560417
• Physical Description: Solid
• Synonyms: malonyl-CoA, MALONYL COENZYME A, S-(Hydrogen malonyl)coenzyme A, 524-14-1, Coenzyme A, S-(hydrogen propanedioate), CoA, Malonyl, CHEBI:15531, 3-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoic acid, LNB9YCJ9F9, DTXSID40904351, 3′-phosphoadenosine 5′-{3-[(3R)-4-{[3-({2-[(3-carboxyacetyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] dihydrogen diphosphate}, EINECS 208-353-4, 3-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-3-oxopropanoic acid, Coenzyme A, Malonyl, 3′-phosphoadenosine 5′-(3-((3R)-4-((3-((2-((3-carboxyacetyl)sulfanyl)ethyl)amino)-3-oxopropyl)amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl) dihydrogen diphosphate), 3-((2-(3-((2R)-3-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-2-hydroxy-3-methylbutanamido)propanamido)ethyl)sulfanyl)-3-oxopropanoic acid, 3-((2-(3-(3-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-2-hydroxy-3-methylbutanamido)propanamido)ethyl)sulfanyl)-3-oxopropanoic acid, 3-(2-(3-(((2R)-4-((((2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl)methoxy-hydroxyphosphoryl)oxy-hydroxyphosphoryl)oxy-2-hydroxy-3,3-dimethylbutanoyl)amino)propanoylamino)ethylsulfanyl)-3-oxopropanoic acid, 3-{[2-(3-{3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido}propanamido)ethyl]sulfanyl}-3-oxopropanoic acid, DTXCID901333508, 208-353-4, Malonyl CoA, malonyl-coenzyme a, S-Malonyl-CoA, Coenzyme A, S-(hydrogen malonate), omega-Carboxyacyl-CoA, Thiomalonic acid S-ester with coenzyme A, MLC, (2S)-Malonyl-CoA, S-(hydrogen propanedioate, SCHEMBL6450, omega-Carboxyacyl-Coenzyme A, S-(hydrogen propanedioic acid, GTPL5219, S-(hydrogen propanedioate) CoA, CHEMBL1234355, MeSH ID: D008316, BDBM50260111, LMFA07050345, S-(hydrogen propanedioate) Coenzyme A, DB04524, HY-115899, CS-0379299, NS00015050, C00083, C03188, Q51589793, (3S,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphahenicosan-21-oic acid 3,5-dioxide (non-preferred name), 9H-purin-6-amine,9-[5-O-[[[[[(3R)-4-[[3-[[2-[(carboxyacetyl)thio]ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl]oxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-3-O-phosphono-beta-D-rib

Malonyl-CoA is widely used in fatty acid biosynthesis research, serving as a substrate for fatty acid synthase (FAS) and acyl carrier protein (ACP). It is essential for in vitro enzymatic assays investigating lipid metabolism and polyketide synthesis pathways. Researchers also employ Malonyl-CoA in metabolic flux analysis and mitochondrial function studies, particularly in obesity, diabetes, and cancer research.

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