Description

2-Hydroxy-4-(trifluoromethyl)pyridine (CAS No. 50650-59-4) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₄F₃NO. This compound, also known by its IUPAC name 4-(trifluoromethyl)-1H-pyridin-2-one, is a versatile heterocyclic building block widely used in pharmaceutical, agrochemical, and material science research. Its unique trifluoromethyl and hydroxyl functional groups make it an excellent intermediate for synthesizing bioactive molecules and advanced materials. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a white to off-white crystalline powder under inert packaging to maintain stability. Ideal for nucleophilic substitution reactions, metal-catalyzed cross-coupling, and as a ligand precursor. Available in research quantities (100mg to 1kg) with optional COA and NMR spectra.

Properties

• CAS Number: 50650-59-4
• Complexity: 239
• IUPAC Name: 4-(trifluoromethyl)-1H-pyridin-2-one
• InChI: InChI=1S/C6H4F3NO/c7-6(8,9)4-1-2-10-5(11)3-4/h1-3H,(H,10,11)
• InChI Key: IKHLLNMSMFVTLP-UHFFFAOYSA-N
• Exact Mass: 163.02449824
• Molecular Formula: C6H4F3NO
• Molecular Weight: 163.10
• SMILES: C1=CNC(=O)C=C1C(F)(F)F
• Topological: 29.1
• Monoisotopic Mass: 163.02449824
• Synonyms: 2-Hydroxy-4-(trifluoromethyl)pyridine, 50650-59-4, DTXSID20379402, DTXCID30330428, 610-554-0, 4-(trifluoromethyl)pyridin-2-ol, 4-(trifluoromethyl)pyridin-2(1h)-one, 4-(trifluoromethyl)-1H-pyridin-2-one, 4-trifluoromethyl-pyridin-2-ol, MFCD00153195, 4-(Trifluoromethyl)-2-pyridone, 2(1H)-Pyridinone, 4-(trifluoromethyl)-, MFCD09029339, Maybridge3_000683, 4-Trifluoromethylpyridin-2-ol, SCHEMBL1660106, SCHEMBL1931574, SCHEMBL7822757, SCHEMBL9901743, SCHEMBL9902594, SCHEMBL9902924, CHEMBL2323845, SCHEMBL21173622, 4-(Trifluoromethyl)-2-pyridinone, 4-(Trifluoromethyl)pyridine-2-ol, IKHLLNMSMFVTLP-UHFFFAOYSA-M, VODLFQBLXUIESC-UHFFFAOYSA-N, 4-(trifluoromethyl) pyridin-2-ol, HMS1432P01, 4-trifluoromethylpyridine-2(1h)-one, BBL101318, CCG-50732, CL0199, SBB087667, STL555114, AKOS005063407, AKOS015961757, AB04095, CS-W003573, FS-1455, 2-hydroxy-4-(trifluoromethyl)-pyridine, IDI1_012070, AC-23240, CS-10708, SY024702, 4-TRIFLUOROMETHYL-2(1H)-PYRIDINONE, DB-021175, 2-Hydroxy-4-(trifluoromethyl)pyridine, 97%, NS00134141, ST50407544, T2790, EN300-84905, 4-(trifluoromethyl)-1,2-dihydropyridin-2-one, SR-01000640086-1, F8885-0626, Z1741962504

Application

2-Hydroxy-4-(trifluoromethyl)pyridine serves as a key intermediate in the synthesis of trifluoromethylated pharmaceuticals, particularly kinase inhibitors and antiviral agents. Its electron-withdrawing trifluoromethyl group enhances metabolic stability in drug candidates. In agrochemical research, it is employed to develop novel pesticides and herbicides with improved efficacy. The compound also finds use in material science for creating fluorinated liquid crystals and corrosion-resistant coatings. Researchers utilize it as a ligand in catalytic systems for C-C bond formation reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (81.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (18.4%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (81.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (18.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (16.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (81.6%)
• Skin Irrit. 2 (18.4%)
• Eye Dam. 1 (81.6%)
• Eye Irrit. 2A (18.4%)
• STOT SE 3 (16.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.