Description

2-Bromo-4-fluorophenol (CAS No. 496-69-5) is a high-purity halogenated phenol derivative with the molecular formula C₆H₄BrFO. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both bromine and fluorine substituents on the phenolic ring, makes it an ideal intermediate for nucleophilic aromatic substitution reactions, cross-coupling reactions, and other functional group transformations.

Our product is rigorously tested to ensure >98% purity (HPLC/GC), with trace metal analysis available upon request. Supplied in amber glass vials under inert atmosphere to prevent degradation, it is ideal for sensitive applications. SDS, CoA, and NMR spectra are provided for quality assurance.

Key Features:

• CAS: 496-69-5
• Molecular Weight: 191.00 g/mol
• Appearance: White to off-white crystalline solid
• Melting Point: 38-42°C
• Storage: 2-8°C under argon
• Hazard Codes: Corrosive (GHS05), Toxic (GHS06)

Properties

• CAS Number: 496-69-5
• Complexity: 99.1
• IUPAC Name: 2-bromo-4-fluoro-phenol
• InChI: InChI=1S/C6H4BrFO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H
• InChI Key: MEYRABVEYCFHHB-UHFFFAOYSA-N
• Exact Mass: 189.94296
• Molecular Formula: C6H4BrFO
• Molecular Weight: 191.00
• SMILES: C1=CC(=C(C=C1F)Br)O
• Topological: 20.2
• Monoisotopic Mass: 189.94296
• Synonyms: 2-Bromo-4-fluorophenol, 496-69-5, MEYRABVEYCFHHB-UHFFFAOYSA-, DTXSID70345556, DTXCID60296629, 610-467-8, inchi=1/c6h4brfo/c7-5-3-4(8)1-2-6(5)9/h1-3,9h, meyrabveycfhhb-uhfffaoysa-n, 2-bromo-4-fluoro-phenol, MFCD00010614, Phenol, 2-bromo-4-fluoro-, 2-bromo-4-flourophenol, 2-bromo4-fluoro-phenol, 4-Fluoro-2-bromophenol, 2-bromo-4-fluoro phenol, SCHEMBL91229, SCHEMBL5453649, SCHEMBL5961703, 2-Bromo-4-fluorophenol, 98%, SCHEMBL27658120, BCP21692, SBB091219, STL183319, AKOS000120655, AC-3753, CS-W003971, HY-W003971, PS-8366, SY021807, DB-024097, A1722, B1555, NS00123416, ST50827103, EN300-21341, F0001-1292

Application

2-Bromo-4-fluorophenol serves as a versatile intermediate in medicinal chemistry for developing fluorinated drug candidates, particularly kinase inhibitors and antimicrobial agents. It is employed in Suzuki-Miyaura coupling reactions to create biaryl structures common in pharmaceutical scaffolds. Researchers also utilize it as a precursor for synthesizing liquid crystal materials and advanced polymer modifiers.

Safety and Hazards

GHS Hazard Statements

• H302 (94.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (94.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.