Description

2-Bromo-4-methylpyridine (CAS No. 4926-28-7) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₆BrN. This versatile organic intermediate is widely utilized in pharmaceutical synthesis, agrochemical development, and material science research. The compound features a bromine substituent at the 2-position and a methyl group at the 4-position of the pyridine ring, offering unique reactivity for cross-coupling reactions and functional group transformations. Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed containers under inert atmosphere to maintain stability. Available in quantities from grams to kilograms, it is ideal for medicinal chemistry, ligand design, and heterocyclic compound synthesis. Store in a cool, dry place protected from light.

Properties

• CAS Number: 4926-28-7
• Complexity: 74.9
• IUPAC Name: 2-bromo-4-methyl-pyridine
• InChI: InChI=1S/C6H6BrN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
• InChI Key: LSZMVESSGLHDJE-UHFFFAOYSA-N
• Exact Mass: 170.96836
• Molecular Formula: C6H6BrN
• Molecular Weight: 172.02
• SMILES: CC1=CC(=NC=C1)Br
• Topological: 12.9
• Monoisotopic Mass: 170.96836
• Synonyms: 2-Bromo-4-methylpyridine, 4926-28-7, DTXSID00370114, DTXCID90321150, 625-590-2, 2-Bromo-4-picoline, 2-Bromo-4-methyl-pyridine, MFCD00082590, 2-Bromo-4-methyl pyridine, Pyridine, 2-bromo-4-methyl-, 4-METHYL-2-BROMOPYRIDINE, 4-Methyl-2-bromopyridine; 2-Bromo-4-methylpyridine;, 2-Bromo4-methylpyridine, 2-bromo 4-methylpyridine, 2-bromo4-methyl-pyridine, 2-Brorno-4-methylpyridine, 2-Bromo-4-methylpyridine (2-Bromo-4-picoline), SCHEMBL130232, SCHEMBL1311184, SCHEMBL2225750, SCHEMBL3135272, SCHEMBL4928793, 2-Bromo-4-methylpyridine, 97%, LSZMVESSGLHDJE-UHFFFAOYSA-N, AB2694, BBL100698, SBB054348, STL554492, AKOS005145600, AB03099, AC-2539, CS-W007579, FB11223, FG-0481, HY-W007579, BP-21189, SY001870, A7370, B2112, ST50826854, EN300-65890, Z851792570

Application

2-Bromo-4-methylpyridine serves as a key building block in Suzuki-Miyaura and Negishi cross-coupling reactions for pharmaceutical intermediates. It is particularly valuable in the synthesis of kinase inhibitors and receptor modulators in drug discovery. The compound also finds use in agricultural chemistry for developing novel crop protection agents. Researchers employ it as a precursor for functionalized pyridine derivatives in material science applications.

Safety and Hazards

GHS Hazard Statements

• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (14.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (16.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (89.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.3%)
• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (16.3%)
• STOT SE 3 (89.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.