Description

1,4-Dioxaspiro[4.5]decan-8-one (CAS No. 4746-97-8) is a highly versatile cyclic ketal derivative of 1,4-cyclohexanedione, widely used in organic synthesis and pharmaceutical research. With the molecular formula C₈H₁₂O₃, this compound features a spirocyclic structure that enhances its stability and reactivity in various chemical transformations. It serves as a key intermediate in the synthesis of complex molecules, including pharmaceuticals, agrochemicals, and specialty chemicals. Available in high purity (≥97%), this product is ideal for researchers requiring precise and reproducible results. Packaged under inert conditions to ensure longevity, it is suitable for use in sensitive applications such as asymmetric synthesis, catalysis, and material science.

Properties

• CAS Number: 4746-97-8
• Complexity: 158
• IUPAC Name: 1,4-dioxaspiro[4.5]decan-8-one
• InChI: InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2
• InChI Key: VKRKCBWIVLSRBJ-UHFFFAOYSA-N
• Exact Mass: 156.078644241
• Molecular Formula: C8H12O3
• Molecular Weight: 156.18
• SMILES: C1CC2(CCC1=O)OCCO2
• Topological: 35.5
• Monoisotopic Mass: 156.078644241
• Synonyms: 1,4-Dioxaspiro[4.5]decan-8-one, 4746-97-8, 1,4-Cyclohexanedione monoethylene acetal, 1,4-Cyclohexanedione monoethylene ketal, 1,4-dioxaspiro(4.5)decan-8-one, VKRKCBWIVLSRBJ-UHFFFAOYSA-, 4,4-(Ethylenedioxy)cyclohexanone, DTXSID00340791, 1,4-Dioxa-(4,5)spiro-8-decanone, 1,4-Cyclohexanedione, cyclic 1,2-ethanediyl acetal, 1,4-dioxaspiro{4.5}decan-8-one, 1,4-Dioxaspiro4.5decan-8-one, DTXCID20291872, 610-352-2, inchi=1/c8h12o3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6h2, vkrkcbwivlsrbj-uhfffaoysa-n, 1,4-Cyclohexanedione monoethyleneacetal, MFCD00010214, 1,4-Cyclohexanedione Monoethyleneketal, 1,4-DIOXA-SPIRO[4.5]DECAN-8-ONE, Cyclohexane-1,4-dione monoethylene ketal, SCHEMBL46361, ,4-Dioxaspiro[4.5]decan-8-one, HMS1668A09, 1,4-dioxaspiro[4.5]decan-8-on, 1,4 cyclohexanedione ethylene ketal, 1,4 dioxaspiro[4,5]decan-8-one, 1,4-cyclohexanedione ethylene ketal, 1,4-dioxaspiro[4,5]decan-8-one, 1.4-dioxaspiro[4.5]decan-8-one, BCP27579, STR01678, 1,4-dioxaspiro[4,5]decane-8-one, 1,4-dioxaspiro[4.5]decane-8-one, 8-oxo-1,4-dioxaspiro[4.5]decane, 1,4-dioxa-spiro[4,5]decan-8-one, 1,4-dioxaspiro[4.5]-decan-8-one, 1.4-dioxa-spiro[4.5]decan-8-one, AC-292, BBL034658, CCG-41335, SBB059360, STL185661, 1,4-cyclohexandione monoethylene ketal, 1,4-cyclohexandione monoethyleneacetal, 1,4-cylohexanedione monoethylene ketal, 1,4-dioxa-spiro[4.5] decan-8-one, 1,4-dioxa-spiro[4.5]-decan-8-one, 1,4-dioxaspiro-[4.5]-decan-8-one, AKOS005146024, 1,4-cyclohexanedione-monoethyleneacetal, CS-W008827, FC31306, PS-8834, SB67030, 1,4 cyclohexanedione monoethylene ketal, 1,4-cyclohexandione mono-ethylene ketal, 1,4-cyclohexanedione monoethlene acetal, 1,4-cyclohexanedione-monoethylene ketal, 1.4-cyclohexanedione monoethylene ketal, 1,4-cyclohexanedione mono-ethyiene ketal, 1,4-Cyclohexanedione mono-ethylene ketal, 1,4-cyclohexanedione-mono-ethylene ketal, cyclohexane-1,4-dione monoethyleneacetal, cyclohexane-1,4-dione monoetylene acetal, 1,4-cyclo-hexanedione monoethylene acetal, 1,4-cyclohexane-dione monoethylene acetal, 1,4-cyclohexanedione mono-ethylene acetal, 1,4-Cyclohexanedione monoethlylene acetal, HY-75213, SY002973, 1,4-Cyclohexane dione mono ethylene ketal, cyclohexane-1,4-dione-mono ethylene ketal, NS00126015, ST50307138, EN300-26857, 1,4-Cyclohexanedione monoethylene acetal, 97%, SR-01000631422-1, F0001-1264

1,4-Dioxaspiro[4.5]decan-8-one is commonly employed as a protected form of 1,4-cyclohexanedione in organic synthesis, enabling selective reactions at other functional groups. Its spirocyclic ketal structure makes it valuable in the preparation of chiral building blocks for pharmaceuticals and fine chemicals. Researchers also utilize it in the development of novel catalysts and ligands for asymmetric transformations. Additionally, it finds applications in polymer chemistry as a monomer or crosslinking agent.

Safety and Hazards

GHS Hazard Statements

• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (77.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (77.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (77.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (11.1%)
• Skin Irrit. 2 (77.8%)
• Eye Irrit. 2 (77.8%)
• STOT SE 3 (77.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.