Description

Propiolic Acid (CAS No. 471-25-0) is a highly reactive alkyne carboxylic acid with the molecular formula C₃H₂O₂. Also known as 2-Propynoic acid or prop-2-ynoic acid, this compound features a terminal alkyne group adjacent to a carboxylic acid functionality, making it a versatile building block in organic synthesis and pharmaceutical research. With a purity grade suitable for laboratory and industrial applications, our Propiolic Acid is rigorously tested to ensure consistency and performance. Ideal for click chemistry, polymer modification, and as a precursor for heterocyclic compounds, this high-quality chemical is packaged under inert conditions to maintain stability. Available in various quantities to meet both research-scale and bulk requirements.

Properties

• CAS Number: 471-25-0
• Complexity: 84.3
• IUPAC Name: prop-2-ynoic acid
• InChI: InChI=1S/C3H2O2/c1-2-3(4)5/h1H,(H,4,5)
• InChI Key: UORVCLMRJXCDCP-UHFFFAOYSA-N
• Exact Mass: 70.005479302
• Molecular Formula: C3H2O2
• Molecular Weight: 70.05
• SMILES: C#CC(=O)O
• Topological: 37.3
• Monoisotopic Mass: 70.005479302
• Physical Description: Liquid; mp = 9 deg C; Solid or liquid with an odor like acetic acid; mp = 18 deg C; Clear dark yellow liquid; mp = 16-18 deg C;
• Color/Form: Crystals from carbon disulfde
• Odor: Odor resembling acetic acid
• Boiling Point: 144 °C
• Melting Point: 18 °C
• Flash Point: 58 °C – closed cup
• Solubility: Very soluble in water, ether, ethanol, chloroform
• Density: 1.1380 g/cu cm at 20 °C
• Vapor Pressure: 3.5 [mmHg]
• Refractive Index: Index of refraction: 1.4306 at 20 °C/D
• Synonyms: PROPIOLIC ACID, 471-25-0, 2-Propynoic acid, prop-2-ynoic acid, Propynoic acid, Acetylenecarboxylic acid, propiolate, Propinsaeure, Propiolsaeure, propinic acid, UNII-P2QW39G9LZ, EINECS 207-437-8, P2QW39G9LZ, NSC 16152, CHEBI:33199, HSDB 7857, NSC-16152, HC.$.CCOOH, acetylenemonocarboxylic acid, PROPIOLIC ACID [MI], DTXSID6060050, 2-PROPYNE-1-CARBOXYLIC ACID, 2Propynoic acid, Carboxy acetylene, DTXCID1040532, 207-437-8, un2920, uorvclmrjxcdcp-uhfffaoysa-n, Propargylic acid, Propiolic acidd, Carboxyacetylene, MFCD00004360, Acetylenemonocarboxylate, A1BXY, 26969-44-8, Acetylene carboxylic acid, HC.equiv.CCOOH, HC#CCOOH, Propiolic acid, 95%, SCHEMBL1077, SCHEMBL405887, SCHEMBL2645127, CHEMBL1213530, BCP18740, NSC16152, STR03210, BBL011346, s6108, STL146436, AKOS000121542, FP07024, Acetylenecarboxylic acid;Propargylic acid, Propiolic acid, technical, >=95% (T), DB-070776, NS00031666, P0497, EN300-21202, C00804, F10329, Q257590, F2191-0185, Z104493798

Application

Propiolic Acid is widely used as a key intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty polymers. Its alkyne group enables efficient participation in Huisgen cycloaddition (click chemistry) for bioconjugation and material science applications. Researchers also utilize it in the synthesis of heterocycles and as a modifier for polymer backbones to introduce carboxylic acid functionality.

Safety and Hazards

GHS Hazard Statements

• H226: Flammable liquid and vapor [Warning Flammable liquids]
• H301: Toxic if swallowed [Danger Acute toxicity, oral]
• H310: Fatal in contact with skin [Danger Acute toxicity, dermal]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]
• H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P316, P319, P321, P330, P332+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flammable liquids – Category 3
• Acute toxicity – Category 3
• Acute toxicity – Category 2
• Skin corrosion/irritation – Category 2
• Specific target organ toxicity – Single exposure – Category 3

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.