Description

Pyridinium Trifluoroacetate (CAS: 464-05-1) is a high-purity organic salt widely used in chemical synthesis and research applications. Composed of a pyridinium cation and a trifluoroacetate anion (C₇H₆F₃NO₂), this compound is valued for its strong acidic properties and solubility in polar solvents. It serves as an efficient reagent for peptide coupling, esterification, and as a catalyst in organic transformations. With a molecular weight of 193.12 g/mol, it is available in crystalline form and is compatible with anhydrous conditions. Ideal for pharmaceutical, agrochemical, and materials science research, this product meets stringent quality standards (≥98% purity) and is supplied with detailed analytical certifications (NMR, HPLC). Store in a cool, dry place away from moisture.

Properties

• CAS Number: 464-05-1
• Complexity: 114
• IUPAC Name: pyridine;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C5H5N.C2HF3O2/c1-2-4-6-5-3-1;3-2(4,5)1(6)7/h1-5H;(H,6,7)
• InChI Key: NRTYMEPCRDJMPZ-UHFFFAOYSA-N
• Exact Mass: 193.03506292
• Molecular Formula: C7H6F3NO2
• Molecular Weight: 193.12
• SMILES: C1=CC=NC=C1.C(=O)(C(F)(F)F)O
• Topological: 50.2
• Monoisotopic Mass: 193.03506292
• Synonyms: 464-05-1, Pyridinium trifluoroacetate, EINECS 207-345-8, NSC 211755, DTXSID00196831, DTXCID40119322, 207-345-8, Pyridine trifluoroacetate, Pyridine 2,2,2-trifluoroacetate, pyridine; trifluoroacetic acid, MFCD00013072, pyridine;2,2,2-trifluoroacetic acid, Pyridine 2,2,2-trifluoroacetic acid, pyridine; 2,2,2-trifluoroacetic acid, NSC211755, SCHEMBL158703, Pyridine trifluoroacetate, 98%, AKOS015891732, pyridine, 2,2,2-trifluoroacetic acid, NSC-211755, AS-58545, SY102042, DB-051374, Pyridinium Trifluoroacetate; NSC 211755;, CS-0187622, F19827

Pyridinium trifluoroacetate is commonly employed as an acidic catalyst in organic synthesis, particularly in peptide bond formation and esterification reactions. It is also utilized in the preparation of ionic liquids and as a stabilizer for sensitive intermediates. Researchers leverage its strong proton-donating ability in polar aprotic solvents for nucleophilic substitutions. Additionally, it finds use in analytical chemistry as a derivatization agent for mass spectrometry.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.