Description

Fluorocholine Chloride (CAS: 459424-38-5) is a high-purity choline derivative with a fluoromethyl substitution, designed for advanced research applications in molecular imaging, radiochemistry, and neurobiology. This compound, with the molecular formula C₅H₁₃ClFNO, serves as a critical precursor for the synthesis of radiolabeled probes, particularly in positron emission tomography (PET) studies targeting choline metabolism in cancer and neurological disorders. Its structural modification enhances cellular uptake and metabolic stability, making it ideal for in vitro and in vivo tracer studies. Packaged under inert conditions to ensure stability, our Fluorocholine Chloride is rigorously tested via HPLC, NMR, and mass spectrometry to meet ≥90% purity standards, with optional isotopic labeling (e.g., ¹⁸F) available upon request. Compatible with automated synthesis modules for streamlined radiopharmaceutical production.

Properties

• CAS Number: 459424-38-5
• Complexity: 65.4
• IUPAC Name: fluoromethyl-(2-hydroxyethyl)-dimethyl-ammonium;chloride
• InChI: InChI=1S/C5H13FNO.ClH/c1-7(2,5-6)3-4-8;/h8H,3-5H2,1-2H3;1H/q+1;/p-1
• InChI Key: QJEHIIJVWXGJAB-UHFFFAOYSA-M
• Exact Mass: 157.0669699
• Molecular Formula: C5H13ClFNO
• Molecular Weight: 157.61
• SMILES: C[N+](C)(CCO)CF.[Cl-]
• Topological: 20.2
• Monoisotopic Mass: 157.0669699
• Synonyms: Fluorocholine chloride, 805-617-6, 459424-38-5, Fluorocholine, n-(fluoromethyl)-2-hydroxy-n,n-dimethylethanaminium chloride, Fluorocholine (chloride), Dimethyl(fluoromethyl)(2-hydroxyethyl)ammonium chloride, Ethanaminium,N-(fluoromethyl)-2-hydroxy-N,N-dimethyl-, chloride (9CI), fluoromethyl-(2-hydroxyethyl)-dimethylazanium;chloride, CCRIS 9400, Fluoromethylcholine Chloride (>90%), Ethanaminium, N-(fluoromethyl)-2-hydroxy-N,N-dimethyl-, chloride, N-Fluoromethyl-2-hydroxy-N,N-dimethylethanaminium chloride, MFCD07995053, NSC720948, (fluoromethyl)(2-hydroxyethyl)dimethylazanium chloride, SCHEMBL7240345, CHEMBL5286912, SBB087248, AKOS006227819, FF59594, NSC-720948, AS-72562, DB-429660, HY-107351, CS-0028197, W18955, 2-[(fluoromethyl)dimethylamino]ethan-1-ol, chloride, Ethanaminium,N-dimethyl-N-(fluoromethyl)-2-hydroxy-, chloride, N-FLUOROMETHYL-2-HYDROXY-N,N-DIMETHYL-ETHANEAMMONIUM CHLORIDE, N-(FLUOROMETHYL)-2-HYDROXY-N,N-DIMETHYLETHAN-1-AMINIUM CHLORIDE

Fluorocholine Chloride is widely utilized in PET imaging as a biomarker for oncological research, particularly in prostate and brain tumors, due to its role in phospholipid metabolism. It enables non-invasive tracking of choline kinase activity, a key enzyme in cancer proliferation. Researchers also employ it in neurotransmitter studies to investigate acetylcholine-related pathways. Its fluoromethyl group allows for facile radiolabeling with ¹⁸F for high-contrast imaging. Suitable for cell uptake assays and pharmacokinetic modeling.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.