Description

1-Fluoro-4-methoxybenzene (CAS No. 459-60-9), also known as 4-Fluoroanisole, is a high-purity aromatic compound with the molecular formula C₇H₇FO. This specialized chemical is widely utilized in organic synthesis, pharmaceutical research, and material science due to its unique structural properties. The compound features a fluorine atom and a methoxy group in the para position on the benzene ring, making it a valuable intermediate for nucleophilic substitution reactions and cross-coupling methodologies.

Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed, light-resistant containers to maintain stability. Ideal for researchers requiring precise fluorinated building blocks, 1-Fluoro-4-methoxybenzene is available in quantities ranging from grams to kilograms, with custom packaging options upon request. SDS and analytical certificates are provided for quality assurance.

Properties

• CAS Number: 459-60-9
• Complexity: 77
• IUPAC Name: 1-fluoro-4-methoxy-benzene
• InChI: InChI=1S/C7H7FO/c1-9-7-4-2-6(8)3-5-7/h2-5H,1H3
• InChI Key: VIPWUFMFHBIKQI-UHFFFAOYSA-N
• Exact Mass: 126.048093005
• Molecular Formula: C7H7FO
• Molecular Weight: 126.13
• SMILES: COC1=CC=C(C=C1)F
• Topological: 9.2
• Monoisotopic Mass: 126.048093005
• Synonyms: 4-Fluoroanisole, 459-60-9, Anisole, p-fluoro-, p-Fluoromethoxybenzene, p-Methoxyfluorobenzene, Benzene, 1-fluoro-4-methoxy-, p-Fluorophenyl methyl ether, NSC 4672, EINECS 207-295-7, AI3-10595, Anisole, p-fluoro-(8CI), 207-295-7, 1-FLUORO-4-METHOXYBENZENE, p-Fluoroanisole, 1-fluoro-4-methoxy-benzene, MFCD00000348, NSC-4672, 4-Fluoroanisole–d4, 4-fluoroanisol, 4-METHOXYFLUOROBENZENE, 4-Fluorophenyl methyl ether, 4-fluoranisole, 4-Fluoro-anisole, NSC4672, 4-fluoromethoxybenzene, 4-Methoxyphenyl fluoride, PARA-FLUOROANISOLE, 4-Fluoroanisole, 99%, 4-Fluoro-1-methoxybenzene, SCHEMBL8298, SCHEMBL75249, SCHEMBL161096, SCHEMBL163245, F6A62M57LM, DTXSID3060033, SCHEMBL12015227, BCP24441, CK1195, SBB085645, AKOS005259464, CS-W016565, PS-9186, PD065658, DB-024091, F0231, NS00044112, ST51038592, EN300-16113, Q63395414, Z53834743, F0001-1244

Application

1-Fluoro-4-methoxybenzene serves as a key precursor in the synthesis of pharmaceuticals, agrochemicals, and liquid crystals. Its electron-withdrawing fluorine and electron-donating methoxy group enable selective functionalization in Pd-catalyzed coupling reactions. Researchers also employ it as a solvent additive in electrochemical studies and as a standard in GC-MS method development for aromatic fluorinated compounds.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.